32988-50-4 Usage
Description
Viomycin, also known as Viocin, is a cyclic peptide antibiotic derived from the actinomycete Streptomyces puniceus. It is characterized by its potent activity against Mycobacterium tuberculosis, the bacterium responsible for tuberculosis. Viomycin's unique structure and mechanism of action make it a valuable addition to the arsenal of antibiotics used to combat drug-resistant tuberculosis strains.
Uses
Used in Pharmaceutical Industry:
Viomycin is used as an antibiotic for the treatment of tuberculosis, particularly in cases where other first-line antibiotics have failed or are not effective. It works by inhibiting protein synthesis in the bacteria, thereby stopping their growth and multiplication.
Used in Research and Development:
In addition to its clinical use, viomycin is also utilized in research settings to study the mechanisms of antibiotic resistance and the development of new drugs to combat drug-resistant tuberculosis. Its unique mode of action provides valuable insights into the biology of Mycobacterium tuberculosis and the potential for designing novel therapeutic strategies.
Used in Combination Therapy:
Viomycin is often used in combination with other antibiotics, such as isoniazid, rifampicin, and ethambutol, to enhance the effectiveness of tuberculosis treatment and reduce the likelihood of drug resistance developing. This multi-drug approach is crucial in managing the global health threat posed by drug-resistant tuberculosis strains.
Originator
Vinactane,Ciba,US ,1953
Indications
Viomycin is a complex polypeptide antibiotic that is active
against MDR strains of tuberculosis. Cross-resistance
between viomycin and kanamycin is less frequent
than between viomycin and capreomycin.
Manufacturing Process
Viomycin is produced by inoculating a nutrient medium with a viable strain of
the organism Actinomyces vinaceus. A method for the production of viomycin
is set forth in US Patent 2,663,445 comprising inoculating a medium
containing soy peptone, beef extract, dextrose, sodium chloride and a silicone
antifoaming agent with a spore suspension of Actinomyces vinaceus and
incubating the inoculated medium for 120 hours at a temperature of 26°C
while passing sterile air through the medium at a rate of 500 ml per liter of
medium per minute.
Therapeutic Function
Antitubercular
Biological Activity
Member of the tuberactinomycin family of antibiotics . Inhibits group I intron splicing and prokaryotic protein synthesis. Freezes bacterial ribosomes in either the pre- or post-translational state. Facilitates trans -cleavage of the Neurospora VS ribozyme.
Check Digit Verification of cas no
The CAS Registry Mumber 32988-50-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,9,8 and 8 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 32988-50:
(7*3)+(6*2)+(5*9)+(4*8)+(3*8)+(2*5)+(1*0)=144
144 % 10 = 4
So 32988-50-4 is a valid CAS Registry Number.
InChI:InChI=1/C25H43N13O10/c26-3-1-2-10(27)4-16(41)32-12-6-30-23(47)18(11-5-17(42)37-24(28)36-11)38-20(44)13(7-31-25(29)48)33-21(45)14(8-39)35-22(46)15(9-40)34-19(12)43/h7,10-12,14-15,17-18,39-40,42H,1-6,8-9,26-27H2,(H,30,47)(H,32,41)(H,33,45)(H,34,43)(H,35,46)(H,38,44)(H3,28,36,37)(H3,29,31,48)/b13-7-/t10-,11+,12-,14-,15-,17-,18-/m0/s1
