330-49-4

Basic information

• Product Name: 1-(3-fluorobenzyl)pyridin-1-ium bromide
• Synonyms: 1-(3-fluorobenzyl)pyridin-1-ium bromide
• CAS NO: 330-49-4
• Molecular Weight: 268.128
• Mol File: 330-49-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(3-fluorobenzyl)pyridin-1-ium bromide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-fluorobenzyl)pyridin-1-ium bromide(330-49-4)
• EPA Substance Registry System: 1-(3-fluorobenzyl)pyridin-1-ium bromide(330-49-4)

Safety Data

• Hazardous Substances Data: 330-49-4(Hazardous Substances Data)

Upstream product

• 110-86-1 pyridine 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 

Relevant articles and documents

Application of primary halogenated hydrocarbons for the synthesis of 3-Aryl and 3-Alkyl indolizines

Indolizine is an important heterocyclic compound with several interesting properties that make it suitable for numerous applications in many fields, such as biology, medicine and materials. However, the synthesis of 3-Alkyl indolizines from bulky primary halogenated alkanes has not yet been reported. Herein, a transition-metal-free synthetic route to 3-Aryl and 3-Alkyl indolizines from electron-deficient alkenes, pyridines and primary halogenated hydrocarbons has been reported for the first time using a tandem reaction. The key step of this method is the oxidative dehydrogenative aromatization of a tetrahydroindolizine intermediate with 2,2,6,6-Tetramethylpiperidine-N-oxyl (TEMPO) as the oxidant. The advantages of this protocol are its use of easily available and low-cost starting materials, the transition-metal-free conditions and its ready scalability.