330-95-0 Usage
Description
Nicarbazin, an organic molecular entity, is an equimolar complex of 4,4'-Dinitrocarbanilide and 2-Hydroxy-4,6-dimethylpyrimidine. It is a light yellow crystalline powder, odorless, with a melting point of 265-275°C (decomposition). It is non-hygroscopic, insoluble in water, ethanol, chloroform, and ether, and slightly soluble in dimethylformamide. Nicarbazin decomposes slowly when ground with water and more rapidly in dilute acid. It serves as a coccidiostat for poultry, acting as an antiprotozoal agent against Coccidia parasites.
Uses
Used in Poultry Industry:
Nicarbazin is used as a coccidiostat for poultry, specifically to combat Coccidia parasites that cause coccidiosis, a disease affecting the intestinal tract of birds. Its application helps improve the health and productivity of poultry.
Used in Wildlife Management:
Nicarbazin is used as a contraceptive for resident Canada geese and waterfowl, helping to control their populations and reduce potential negative impacts on the environment and human activities.
Used in Avian Reproduction Studies:
Nicarbazin is employed in the study of avian reproduction, particularly to interfere with the formation of the vitelline (yolk) membrane in bird eggs. This application aids researchers in understanding the reproductive processes and development in birds.
Used in Pharmaceutical Research:
Nicarbazin has been utilized to study the effects of delivery methods on plasma levels of 4,4′-dinitrocarbanilide (DNC), the active anticoccidial component of Nicarbazin. This research contributes to the development of more effective and targeted treatments for coccidiosis in poultry.
Biochem/physiol Actions
Nicarbazin, an effective anticoccidial, is also a wide-spectrum anti-parasitic drug. It affects avian reproduction by reducing egg production, egg weight, and egg hatchability. The mechanism of action of Nicarbazin is unknown.
Mode of action
Nicarbazin interferes with the formation of the vitelline membrane, separating the egg yolk and egg white. The exact mode of action is unknown, although it is thought nicarbazin interferes with cholesterol metabolism in the formation of the membrane. Eggs from treated birds are described as mottled in appearance, reflecting a porous vitelline membrane. The effect on hatchability is a function of time and dose and the effect is reversible.
Check Digit Verification of cas no
The CAS Registry Mumber 330-95-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 0 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 330-95:
(5*3)+(4*3)+(3*0)+(2*9)+(1*5)=50
50 % 10 = 0
So 330-95-0 is a valid CAS Registry Number.
InChI:InChI=1/C13H10N4O5.C6H8N2O/c18-13(14-9-1-5-11(6-2-9)16(19)20)15-10-3-7-12(8-4-10)17(21)22;1-4-3-5(2)8-6(9)7-4/h1-8H,(H2,14,15,18);3H,1-2H3,(H,7,8,9)
330-95-0Relevant articles and documents
Process for formulating a synthetic drug for use in animal feed, and resulting formulation
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, (2008/06/13)
A method of formulating a synthetic drug for use in animal feed, for the purpose of reducing carry-over of the synthetic drug to subsequent lots of animal feed in the feed mill.
