33037-08-0

Basic information

• Product Name: [3-(3-nitrophenyl)oxiran-2-yl](phenyl)methanone
• CAS NO: 33037-08-0
• Molecular Formula: C₁₅H₁₁NO₄
• Molecular Weight: 269.2521
• Mol File: 33037-08-0.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 436.8°C at 760 mmHg
• Flash Point: 196.9°C
• Density: 1.364g/cm³
• Vapor Pressure: 7.87E-08mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: [3-(3-nitrophenyl)oxiran-2-yl](phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(3-nitrophenyl)oxiran-2-yl](phenyl)methanone(33037-08-0)
• EPA Substance Registry System: [3-(3-nitrophenyl)oxiran-2-yl](phenyl)methanone(33037-08-0)

Safety Data

• Hazardous Substances Data: 33037-08-0(Hazardous Substances Data)

Usage

Description

[3-(3-nitrophenyl)oxiran-2-yl](phenyl)methanone, also known as N-phenyl-3-(3-nitrophenyl)-2-oxiranylmethanone, is a complex ketone derivative featuring a phenyl group and a nitrophenyl oxiran-2-yl group. [3-(3-nitrophenyl)oxiran-2-yl](phenyl)methanone is recognized for its unique structure and reactivity, making it a valuable intermediate in the synthesis of various organic compounds. Its application in pharmaceutical research and organic synthesis is significant, although its complexity and potential hazards necessitate careful handling and disposal to ensure safety for human health and the environment.

Uses

Used in Organic Synthesis:
[3-(3-nitrophenyl)oxiran-2-yl](phenyl)methanone is used as a key intermediate in the production of a wide range of organic compounds. Its unique structure allows for versatile reactions and the creation of diverse chemical products.
Used in Pharmaceutical Research:
In the pharmaceutical industry, [3-(3-nitrophenyl)oxiran-2-yl](phenyl)methanone serves as an essential building block for the development of new drugs. Its reactivity and structural properties contribute to the design and synthesis of novel pharmaceutical agents.
Used in Chemical Research and Development:
[3-(3-nitrophenyl)oxiran-2-yl](phenyl)methanone is also utilized in the field of chemical research and development, where its properties are explored for potential applications in creating new materials, improving existing processes, and advancing the understanding of chemical reactions and mechanisms.

Upstream product

• 124-38-9 carbon dioxide 
• 99-61-6 3-nitro-benzaldehyde 
• 70-11-1 α-bromoacetophenone 
• 614-48-2 (E)-3-nitrochalcone 
• 614-48-2 3-nitrochalcone 
• 532-27-4 1-chloroacetophenone 
• 98-86-2 acetophenone 

Downstream Products

• 93850-84-1 [(4S,5R)-2,2-Dimethyl-5-(3-nitro-phenyl)-[1,3]dioxolan-4-yl]-phenyl-methanone 
• 56856-43-0 1-(3-nitrophenyl)-2-phenylethane-1,2-dione 
• 1345732-72-0 (Z)-2-chloro-3-(3-nitrophenyl)-1-phenylpropen-1-one 
• 1217439-15-0 C₂₃H₁₈N₂O₄ 
• 16860-55-2 5-(3-nitrophenyl)-1,3-diphenyl-1H-pyrazole 
• 964-91-0 5-(3-nitrophenyl)-3-phenylisoxazole 
• 614-48-2 3-nitrochalcone 
• 37975-15-8 1-(3'-nitrophenyl)-3-phenylpropane-1,3-dione 

Relevant articles and documents

Asymmetric Epoxidation of Enones Promoted by Dinuclear Magnesium Catalyst

Asymmetric synthesis with cheaper and non-toxic alkaline earth metal catalysts is becoming an important and sustainable alternative to conventional catalytic methodologies mostly relying on precious metals. In spite of some sustainable methods for enantioselective epoxidation of enones, the development of a well-defined and efficient catalyst based on magnesium complexes for these reactions is still a challenging task. In this perspective, we present the application of chiral dinuclear magnesium complexes for asymmetric epoxidation of a broad range of electron-deficient enones. We demonstrate that the in situ generated magnesium-ProPhenol complex affords enantioenriched oxiranes in high yields and with excellent enantioselectivities (up to 99% ee). Our extensive study verifies the literature data in this area and provides a step forward to better understand the factors controlling the oxygenation process. Elaborated catalyst offers mild reaction conditions and a truly wide substrate scope. (Figure presented.).

Metal-Free and Efficient Epoxidation of α,β-Unsaturated Ketones with 1,1,2,2-Tetrahydroperoxy-1,2-Diphenylethane as a Powerful Solid Oxidant

1,1,2,2-Tetrahydroperoxy-1,2-diphenylethane was used for the efficient and metal-free epoxidation of various α,β-unsaturated ketones, carried out under mild alkaline conditions at room temperature.

Intramolecular Friedel-Crafts alkylation of chalcone epoxides using indium(III) chloride as an efficient catalyst

Indium(III) chloride catalyzes the ring opening of chalcone epoxides followed by intramolecular Friedel-Crafts alkylation under mild conditions at room temperature to afford highly functionalized 3-aryl-2-hydroxy-2,3-dihydro- 1H-inden-1-ones in excellent yields (81-95%). Georg Thieme Verlag Stuttgart, New York.