3306-18-1

Basic information

• Product Name: 3,7-bis-benzyloxy-2-(3,4-dimethoxy-phenyl)-5-methoxy-chromen-4-one
• Synonyms: 3,7-bis-benzyloxy-2-(3,4-dimethoxy-phenyl)-5-methoxy-chromen-4-one
• CAS NO: 3306-18-1
• Molecular Weight: 524.57
• Mol File: 3306-18-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3,7-bis-benzyloxy-2-(3,4-dimethoxy-phenyl)-5-methoxy-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,7-bis-benzyloxy-2-(3,4-dimethoxy-phenyl)-5-methoxy-chromen-4-one(3306-18-1)
• EPA Substance Registry System: 3,7-bis-benzyloxy-2-(3,4-dimethoxy-phenyl)-5-methoxy-chromen-4-one(3306-18-1)

Safety Data

• Hazardous Substances Data: 3306-18-1(Hazardous Substances Data)

Upstream product

• 77-78-1 dimethyl sulfate 
• 498548-15-5 3,7-bis(benzyloxy)-2-(3,4-dihydroxyphenyl)-5-hydroxy-4H-chromen-4-one 

Downstream Products

• 3306-16-9 2-(3,4-dimethoxyphenyl)-3,7-dihydroxy-5-methoxy-4H-chromen-4-one 

Relevant articles and documents

Quercetin derivative and its preparation method and application

The invention discloses a quercetin derivative and a preparation method and application thereof. The preparation method comprises the following steps: firstly using dichlorodiphenylmethane to protect quercetin o-diphenol hydroxyl, combining a benzyl protection group to obtain the selectively protected quercetin derivative, and then independently reacting with dimethyl sulfate, diethyl sulfate, allyl bromide, paratoluensulfonyl chloride and acetic anhydride respectively to generate corresponding quercetin derivatives. All of the prepared derivative compounds have NRK-49F proliferation activity inhibition superior to that of quercetin. The quercetin derivatives 20a-1, 14a-1 and 23d-1 compositely replaced by methyl and p-tosyl have higher inhibition NRK-49F proliferation activity, and the inhibition ratio respectively reaches 86.33%, 78.04% and 75.91%. Thus, the currently obtained quercetin derivative compounds have obvious inhibition effect on kidney fibroblast NRK-49F proliferation.