3307-88-8

Basic information

• Product Name: 3-ethoxycarbonylacrylonitrile
• CAS NO: 3307-88-8
• Molecular Weight: 125.127
• Mol File: 3307-88-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-ethoxycarbonylacrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ethoxycarbonylacrylonitrile(3307-88-8)
• EPA Substance Registry System: 3-ethoxycarbonylacrylonitrile(3307-88-8)

Safety Data

• Hazardous Substances Data: 3307-88-8(Hazardous Substances Data)

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 113379-95-6 Trifluoro-methanesulfonate3,5-dimethyl-2-phenyl-oxazol-3-ium; 
• 623-47-2 propynoic acid ethyl ester 
• 113379-75-2 2-Benzoyl-1-methyl-1H-pyrrole-3,4-dicarboxylic acid dimethyl ester 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 

Downstream Products

• 92885-10-4 ethyl 1-benzyl-4-cyanomethyl-2-methyl-5-oxo-3-pyrrolinecarboxylate 

Relevant articles and documents

Catalytic Hydrocyanation of Activated Terminal Alkynes

A universal, practical and scalable organocatalytic hydrocyanation manifold to provide β-substituted acrylonitriles bearing an electron-withdrawing functionality has been implemented. The catalytic manifold operates under the reactivity generation principle “a good nucleophile generates a strong base”, and it uses 1,4-diazabicyclo[2.2.2]octane (DABCO) as the catalyst, activated terminal alkynes as substrates and acetone cyanohydrin as the cyanide source. The acrylonitriles obtained as E,Z mixtures are straightforwardly resolved by simple flash chromatography delivering the pure isomers in preparative amounts.