33097-38-0

Basic information

• Product Name: 3-chloro-6-fluoropyridazine
• Synonyms: 3-chloro-6-fluoropyridazine;Pyridazine, 3-chloro-6-fluoro-
• CAS NO: 33097-38-0
• Molecular Formula: C4H2ClFN2
• Molecular Weight: 132.5234832
• Mol File: 33097-38-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 243.9±20.0 °C(Predicted)
• Appearance: /
• Density: 1.439±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -1.04±0.10(Predicted)
• CAS DataBase Reference: 3-chloro-6-fluoropyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-6-fluoropyridazine(33097-38-0)
• EPA Substance Registry System: 3-chloro-6-fluoropyridazine(33097-38-0)

Safety Data

• Hazardous Substances Data: 33097-38-0(Hazardous Substances Data)

Usage

General Description

3-chloro-6-fluoropyridazine is a chemical compound belonging to the category of organic compounds known as pyridazines and derivatives. These are compounds containing a pyridazine ring, which is a six-membered aromatic ring with two nitrogen atoms at positions 1 and 2 and four carbon atoms. Its molecular formula is C4H2ClFN2. This chemical is primarily used in the manufacturing of pharmaceuticals and other organic compounds. Its features, such as the presence of chlorine and fluorine atoms, make it a useful substance for synthesizing various complex molecules. In terms of safety, specific information may not be available, hence it's always advised to handle it with the same safety precautions as with other chemicals, which includes avoiding direct contact or inhalation, and using it in well-ventilated areas.

Upstream product

• 5469-69-2 6-chloro-pyridazin-3-ylamine 
• 141-30-0 3,6-dichlorpyridazine 

Relevant articles and documents

Deaminative chlorination of aminoheterocycles

Selective modification of heteroatom-containing aromatic structures is in high demand as it permits rapid evaluation of molecular complexity in advanced intermediates. Inspired by the selectivity of deaminases in nature, herein we present a simple methodology that enables the NH2 groups in aminoheterocycles to be conceived as masked modification handles. With the aid of a simple pyrylium reagent and a cheap chloride source, C(sp2)?NH2 can be converted into C(sp2)?Cl bonds. The method is characterized by its wide functional group tolerance and substrate scope, allowing the modification of >20 different classes of heteroaromatic motifs (five- and six-membered heterocycles), bearing numerous sensitive motifs. The facile conversion of NH2 into Cl in a late-stage fashion enables practitioners to apply Sandmeyer- and Vilsmeier-type transforms without the burden of explosive and unsafe diazonium salts, stoichiometric transition metals or highly oxidizing and unselective chlorinating agents. [Figure not available: see fulltext.]

Selective fluorination by halogen exchange of chlorodiazines and chloropyridines promoted by the 'proton sponge' - Triethylamine tris(hydrogen fluoride) system

The 'proton sponge' - triethylamine tris(hydrogen fluoride) mixtures provide a mild and efficient fluorinating reagent to introduce selectively fluorine atoms by halogen exchange into chlorodiazines and chloronitropyridine series.

Halogen-Exchange Fluorination of Aromatic Halides with HF or HF-Base

Heteroatomic halides such as 2-chloropyrimidines and 2-chloropyridines, and 2,4-dinitrochlorobenzene underwent halogen-exchange fluorination with the treatment of HF or HF-base solutions to afford the corresponding fluorides in good yields.