330977-65-6

Basic information

• Product Name: 5-(5-formylfuran-2-yl)-2-hydroxybenzoic acid
• Synonyms: 5-(5-formylfuran-2-yl)-2-hydroxybenzoic acid
• CAS NO: 330977-65-6
• Molecular Weight: 232.193
• Mol File: 330977-65-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 245-247 °C(Solv: ethanol (64-17-5))
• Boiling Point: 477.2±45.0 °C(Predicted)
• Density: 1.449±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-(5-formylfuran-2-yl)-2-hydroxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(5-formylfuran-2-yl)-2-hydroxybenzoic acid(330977-65-6)
• EPA Substance Registry System: 5-(5-formylfuran-2-yl)-2-hydroxybenzoic acid(330977-65-6)

Safety Data

• Hazardous Substances Data: 330977-65-6(Hazardous Substances Data)

Upstream product

• 590363-46-5 3-(5-formylfuran-2-yl)-4-hydroxybenzoate methyl ester 
• 27329-70-0 5-formylfurane-2-boronic acid 
• 4068-75-1 methyl 5-iodosalicylate 
• 89-55-4 5-bromosalicyclic acid 
• 98-01-1 furfural 
• 89-57-6 5-Aminosalicylic Acid 
• 119-30-2 2-hydroxy-5-iodobenzoic acid 

Downstream Products

• 1175710-38-9 C₁₅H₁₀N₂O₅S 
• 328268-48-0 C₁₆H₁₀N₂O₆S 

Relevant articles and documents

Synthesis and biological evaluation of novel rhodanine-based structures with antiviral activity towards HHV-6 virus

An increased awareness of diseases associated with Human herpesvirus 6 (HHV-6) infection or reactivation has resulted in a growing interest in the evaluation of the best treatment options available for the clinical management of HHV-6 disease. However, no

Design, synthesis, and biological activity of novel 5-((arylfuran/1 H -pyrrol-2-yl)methylene)-2-thioxo-3-(3-(trifluoromethyl)phenyl) thiazolidin-4-ones as HIV-1 fusion inhibitors targeting gp41

On the basis of our earlier molecular docking analysis, we designed and synthesized 5-((arylfuran/1H-pyrrol-2-yl)methylene)-2-thioxo-3-(3- (trifluoromethyl)phenyl)thiazolidin-4-ones (12a-o) as HIV-1 entry inhibitors. Compounds 12a-o effectively inhibited infection by both laboratory-adapted and primary HIV-1 strains and blocked HIV-1 mediated cell-cell fusion and gp41 six-helix bundle formation. Molecular docking analyses on two highly active inhibitors, 12b, containing a carboxylic acid group, and 12m, containing a tetrazole group, indicated that they both fit snugly into the hydrophobic cavity of HIV-1 gp41 from which each has important ionic interactions with lysine 574 (K574). By contrast, molecular docking of 12i, a less active compound containing a pyrrole instead of a furan ring, indicated a completely different orientation from 12b and 12m and missed critical interactions.

Exploration of novel thiobarbituric acid-, rhodanine- and thiohydantoin-based HIV-1 integrase inhibitors

A novel compound inhibiting HIV-1 integrase has been identified by means of virtual screening techniques. A small family of structurally related molecules has been synthesized and biologically evaluated with some of the compounds possessing micromolar act