3310-47-2

Basic information

• Product Name: (4E)-3-hydroxy-4-imino-1-pentofuranosyl-3,4-dihydropyrimidin-2(1H)-one
• CAS NO: 3310-47-2
• Molecular Formula: C₉H₁₃N₃O₆
• Molecular Weight: 259.216
• Mol File: 3310-47-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 538.2°C at 760 mmHg
• Flash Point: 279.3°C
• Density: 1.96g/cm³
• Vapor Pressure: 7.9E-14mmHg at 25°C
• Refractive Index: 1.762
• CAS DataBase Reference: (4E)-3-hydroxy-4-imino-1-pentofuranosyl-3,4-dihydropyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (4E)-3-hydroxy-4-imino-1-pentofuranosyl-3,4-dihydropyrimidin-2(1H)-one(3310-47-2)
• EPA Substance Registry System: (4E)-3-hydroxy-4-imino-1-pentofuranosyl-3,4-dihydropyrimidin-2(1H)-one(3310-47-2)

Safety Data

• Hazardous Substances Data: 3310-47-2(Hazardous Substances Data)

Usage

General Description

(4E)-3-hydroxy-4-imino-1-pentofuranosyl-3,4-dihydropyrimidin-2(1H)-one is a chemical compound that belongs to the group of nucleoside analogs. It is a derivative of pyrimidine, a heterocyclic compound that is found in DNA and RNA. (4E)-3-hydroxy-4-imino-1-pentofuranosyl-3,4-dihydropyrimidin-2(1H)-one has a pentofuranosyl group, which is a five-carbon sugar, and a dihydropyrimidinone moiety that confers unique biological properties. The presence of a hydroxy and imino group in the molecule makes it potentially important in pharmaceutical research, as it may exhibit antiviral, antitumor, or anti-inflammatory properties. However, further investigation and research are needed to fully understand its potential applications and effects.

Upstream product

• 65-46-3 CYTIDINE 

Downstream Products

• 800379-05-9 1-(3,4-dihydroxy-5-hydroxymethyltetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione 4-(O-benzyloxime) 
• 3258-02-4 uridine 4-oxime 

Relevant articles and documents

Novel cytidine-based orotidine-5′-monophosphate decarboxylase inhibitors with an unusual twist

Orotidine-5′-monophosphate decarboxylase (ODCase) is an interesting enzyme with an unusual catalytic activity and a potential drug target in Plasmodium falciparum, which causes malaria. ODCase has been shown to exhibit unusual and interesting interactions with a variety of nucleotide ligands. Cytidine-5′-monophosphate (CMP) is a poor ligand of ODCase, and CMP binds to the active site of ODCase with an unusual orientation and conformation. We designed N3- and N4-modified CMP derivatives as novel ligands to ODCase. These novel CMP derivatives and their corresponding nucleosides were evaluated against Plasmodium falciparum ODCase and parasitic cultures, respectively. These derivatives exhibited improved inhibition of the enzyme catalytic activity, displayed interesting binding conformations and unusual molecular rearrangements of the ligands. These findings with the modified CMP nucleotides underscored the potential of transformation of poor ligands to ODCase into novel inhibitors of this drug target.

AN IMPROVED PROCEDURE FOR THE PREPARATION OF AROMATIC HETEROCYCLIC N-OXIDES

An improved procedure for the preparation of aromatic heterocyclic N-oxide is described.Nitrogen containing heterocyclic compounds gave their N-oxides in excellent yields by the reaction of m-CPBA in DMF/MeOH in the presence of HF in a short time under mild reaction conditions.The presence of HF and MeOH is crucial for the reaction.

3-HYDROXYURIDINE, AN ALLELOPATHIC FACTOR OF AN AFRICAN TREE, BAILLONELLA TOXISPERMA

A plant growth inhibitor was isolated from Baillonella toxisperma, a plant which may cause an allelopathic effect in the tropical rain forest of Cameroon.From spectral and chemical evidence, the inhibitor was identified as 3-hydroxyuridine.It inhibited both hypocotyl and root growth of cucumber and radish seedlings, and also inhibited root growth of rice seedlings, but not sheath growth.The foliar treatment of 3-hydroxdyuridine exhibited inhibitory effects on the growth of a wide variety of weeds; however, it was quite ineffective against the growth of the crop plant, Zea mays.The strong plant growth inhibitory activity, together with the occurence in most parts of the tree at high levels, indicated that 3-hydroxyuridine may involved in the allelopathy of the tree. - Keywords: Baillonella toxisperma; Sapotaceae; allelopathy; allelochemical; 3-hydroxyuridine; plant growth inhibitor; herbicidal activity.