33100-26-4

Basic information

• Product Name: Benzene, 1-(2-azidoethyl)-2-nitro-
• CAS NO: 33100-26-4
• Molecular Formula: C8H8N4O2
• Molecular Weight: 192.177
• Mol File: 33100-26-4.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(2-azidoethyl)-2-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(2-azidoethyl)-2-nitro-(33100-26-4)
• EPA Substance Registry System: Benzene, 1-(2-azidoethyl)-2-nitro-(33100-26-4)

Safety Data

• Hazardous Substances Data: 33100-26-4(Hazardous Substances Data)

Upstream product

• 15121-84-3 2-nitro-benzeneethanol 
• 16793-89-8 (2-bromoethyl)-2-nitrobenzene 

Downstream Products

• 1602733-18-5 C₂₃H₂₀N₆O₃ 
• 1602731-95-2 C₂₃H₂₀N₆O₃ 
• 1316652-13-7 C₁₇H₁₅N₅O₄ 
• 861337-74-8 2-nitrophenethylamine hydrochloride 
• 33100-15-1 2-(2-aminoethyl)nitrobenzene 

Relevant articles and documents

Sustainable organophosphorus-catalysed Staudinger reduction

A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.

Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries

To find HDAC8-selective inhibitors, we designed a library of HDAC inhibitor candidates, each containing a zinc-binding group that coordinates with the active-site zinc ion, linked via a triazole moiety to a capping structure that interacts with residues on the rim of the active site. These compounds were synthesized by using click chemistry. Screening identified HDAC8-selective inhibitors including C149 (IC50 = 0.070 μM), which was more potent than PCI-34058 (6) (IC50 = 0.31 μM), a known HDAC8 inhibitor. Molecular modeling suggested that the phenylthiomethyl group of C149 binds to a unique hydrophobic pocket of HDAC8, and the orientation of the phenylthiomethyl and hydroxamate moieties (fixed by the triazole moiety) is important for the potency and selectivity. The inhibitors caused selective acetylation of cohesin in cells and exerted growth-inhibitory effects on T-cell lymphoma and neuroblastoma cells (GI50 = 3-80 μM). These findings suggest that HDAC8-selective inhibitors have potential as anticancer agents.

CGRP RECEPTOR ANTAGONISTS

Compounds of Formula (I): and Formula (II): (where variables R2, R4, A, B, D, W, X, Y and Z are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.