3316-46-9

Basic information

• Product Name: APIGENINTRIACETATE
• Synonyms: APIGENINTRIACETATE;4',5,7-Triacetoxyflavone;4',5,7-Trihydroxyflavone triacetate;5,7-Bis(acetyloxy)-2-[4-(acetyloxy)phenyl]-4H-1-benzopyran-4-one
• CAS NO: 3316-46-9
• Molecular Formula: C₂₁H₁₆O₈
• Molecular Weight: 348.37
• Mol File: 3316-46-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 569.5°Cat760mmHg
• Flash Point: 249.6°C
• Appearance: /
• Density: 1.356g/cm³
• Vapor Pressure: 5.55E-13mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: APIGENINTRIACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: APIGENINTRIACETATE(3316-46-9)
• EPA Substance Registry System: APIGENINTRIACETATE(3316-46-9)

Safety Data

• Hazardous Substances Data: 3316-46-9(Hazardous Substances Data)

Usage

Description

Apigenin Triacetate is a chemical compound derived from the flavonoid apigenin, which is found in various plants. It is known for its potential therapeutic properties and is used as an intermediate in the synthesis of other compounds.

Uses

Used in Pharmaceutical Industry:
Apigenin Triacetate is used as an intermediate in the synthesis of Isorhoifolin (I819700), a naturally occurring flavonoid with potential antidiabetic, antihyperlipidemic, and antioxidant effects. This makes it a valuable compound in the development of new drugs for treating diabetes, hyperlipidemia, and other conditions related to oxidative stress.

InChI:InChI=1/C21H16O8/c1-11(22)26-15-6-4-14(5-7-15)18-10-17(25)21-19(28-13(3)24)8-16(27-12(2)23)9-20(21)29-18/h4-10H,1-3H3

Upstream product

• 520-36-5 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one 
• 108-24-7 acetic anhydride 
• 480-41-1 5,7-Dihydroxy-2-(4-hydroxy-phenyl)-chroman-4-on 
• 127-08-2 potassium acetate 
• 73111-01-0 4',5,7-triacetoxyflavan-4-one 
• 10236-47-2 naringin 
• 724434-08-6 dihydrokaempferol 

Downstream Products

• 29781-25-7 apigenin 7-O-β-D-glucopyranosiduronic acid methyl ester 
• 29741-09-1 apigenin-7-O-β-D-glucuronide 
• 34340-20-0 5,4'-diacetoxyflavone-7-O-D-triacetoxyglucuronic acid methyl ester 
• 16280-23-2 4',5,-diacetoxy-7-methoxyflavone 
• 437-64-9 genkwanin 
• 5892-39-7 acacetin diacetate 
• 480-44-4 5,7-dihydroxy-2-(4'-methoxyphenyl)-4H-1-benzopyran-4-one 
• 1610737-95-5 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-7-morpholino-4H-chromen-4-one 
• 1610737-91-1 5-(benzyloxy)-2-(4-(benzyloxy)phenyl)-4-oxo-4Hchromen-7-yl4-methylbenzenesulfonate 
• 1104802-77-8 5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl-4-methylbenzenesulfonate 
• 1610737-85-3 4-(5-acetoxy-4-oxo-7-(tosyloxy)-4H-chromen-2-yl)phenyl acetate 
• 1610737-80-8 4-(5-acetoxy-7-(tert-butoxy)-4-oxo-4H-chromen-2-yl)phenyl acetate 
• 1610737-52-4 4-(5-acetoxy-7-((4-fluorobenzyl)oxy)-4-oxo-4H-chromen-2-yl)phenyl acetate 
• 1610737-74-0 5-hydroxy-2-(4-hydroxyphenyl)-7-morpholino-4H-chromen-4-one 

Relevant articles and documents

Extraction, Isolation and Characterization of Valuable Worked on Acacia Tortilis

Acacia tortilis is one of the important species of genus Acacia belonging to family Leguminaceae. Though there is no more study performed on this plant but it plays important role in the countries where it found. These countries include North Africa, Arabian Peninsula and Asian countries. The various part of Acacia tortilis plant say leaves, pods, gum exudates and bark were used as antidiabetic, antidiarrhoeal, antiasthmatic and also had several other medicinal benefits. The present discussion deals with the isolation and characterization of the following compounds from the leaves of Acacia tortilis. Lupan-3-ol, 12,20-diene, Lupan-12, 20-dien 3-one, Friedelin, ?-amyrin, ?- sitosterol, Apigenin, Luteolin, Quercetin, 5,7-dihydroxy-4-p-methyl benzylisoflavone, Vitexin, 2',6'-dihydroxy chalcone-4'-O-glucoside.

A 5, 4' - dihydroxy flavone - 7 - O - D - glucuronic acid preparation method

The invention relates to the drug synthesis technical field, and in particular, relates to a preparation method of 5,4'-dihydroxy flavone-7-O-D-glucuronic acid. The method comprises the following steps: taking a compound having a structure represented by the formula II, and under an alkaline condition, acylating to obtain a compound having a structure represented by the formula III; taking the compound having the structure represented by the formula III and alpha-bromo triacetoxy methyl glucuronate, and carrying out a glycosylation reaction, to obtain a compound having a structure represented by the formula IV; taking the compound having the structure represented by the formula IV, and hydrolyzing under an acidic condition, to obtain a compound having a structure represented by the formula V; and taking the compound having the structure represented by the formula V, hydrolyzing under an alkaline condition, and thus obtaining the product. The method provided by the invention has the advantages of cheap and easily obtained starting raw materials, less reaction steps, and simple and easily operated process, and is suitable for large-scale industrialized production; and through testing, the purity of the obtained product can reach more than 98%, and the total yield reaches up to 56%.

Design and discovery of flavonoid-based HIV-1 integrase inhibitors targeting both the active site and the interaction with LEDGF/p75

HIV integrase (IN) is an essential enzyme for the viral replication. Currently, three IN inhibitors have been approved for treating HIV-1 infection. All three drugs selectively inhibit the strand transfer reaction by chelating a divalent metal ion in the