33171-05-0Relevant articles and documents
Preparation method 1,7 - di (4 -hydroxy) heptyl -3-5 - glycol ester
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Paragraph 0026; 0035; 0037; 0039-0040, (2021/01/30)
The invention discloses a preparing method of 1,7-bis(4-benzene hydroxyl)heptyl-3,5-glycol ester. The method includes the following steps of firstly, conducting a -C=C- reduction reaction with bisdemethoxycurcumin as the raw material to obtain a product 3; secondly, conducting a reduction reaction of carbonyl on the premise of protecting hydroxyl on a benzene ring to obtain a product 5; secondly,conducting an esterification reaction on the product 5 to obtain a product 6, and conducting a protecting group removing reaction on the product 6 to obtain the final product, namely 1,7-bis(4-benzenehydroxyl)heptyl-3,5-glycol ester. By means of the method, through the reduction reaction, the reaction of protecting hydroxyl on the benzene ring, the reaction of reducing carbonyl, the esterification reaction and the protecting group removing reaction, 1,7-bis(4-benzene hydroxyl)heptyl-3,5-glycol ester can be obtained; the reaction process is simple, operation is simple, applied raw materials are low in cost, yield is high, and the method is suitable for industrially producing 1,7-bis(4-benzene hydroxyl)heptyl-3,5-glycol ester on a large scale.
Method for artificially synthesizing curcumin and derivatives thereof
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Paragraph 0026-0027; 0031-0032; 0050-0052, (2020/05/30)
The invention provides a method for artificially synthesizing curcumin and derivatives thereof. The method comprises the following steps: reacting acetylacetone with boron oxide under a weakly acidiccondition to generate a complex, protecting methylene groups between two ketocarbonyl groups, adding a catalyst, reacting the complex with vanillin (benzaldehyde derivative) to obtain a curcumin derivative intermediate (I), and hydrolyzing the intermediate to obtain the curcumin derivative. The selectivity of the reaction is far higher than that of a preparation reaction in an alkaline system, andis macroscopically and specifically embodied in the yield of curcumin and derivatives thereof: in the existing two-pot reaction, the yield of curcumin in the whole process is about 60%; the yield ofthe preparation method can reach 80-90%. Therefore, the method provided by the invention reduces the waste of raw materials and the generation of byproducts; and complete hydrolysis can be realized only at normal temperature, insoluble substances included in the product are almost zero, and the obtained product is pure.
Synthesis, spectral characterization and thermal analysis of rubrocurcumin and its analogues
John, Jeena,Devi, R. Sudha,Balachandran,Babu, K. V. Dinesh
, p. 2301 - 2314 (2017/10/06)
Rubrocurcumin and its analogues were synthesized and characterized by UV, IR, NMR and FT-MS spectral data. Thermal analysis of compounds has been carried out using TG-DTG techniques using non-isothermal heating conditions. Flynn–Wall–Ozawa and Kissinger–Akahira–Sunose isoconversional methods were used to determine the apparent activation energies (Ea) for the thermal decomposition rubrocurcumin and its analogues. The Ea values obtained using these methods were used as reference to determine the most suitable kinetic model using Coats–Redfern method. A possible mechanism is suggested to explain the thermal decomposition process. From the TG-DTG data, kinetic parameters have been calculated and were used to evaluate the thermal stability of compounds and the substituent effect on its thermal stability.
