3319-00-4Relevant articles and documents
Ruthenium-catalyzed /V-alkylation of amines and sulfonamides using borrowing hydrogen methodology
Hamid, M. Haniti S. A.,Allen, C. Liana,Lamb, Gareth W.,Maxwell, Aoife C.,Maytum, Hannah C.,et al.
supporting information; experimental part, p. 1766 - 1774 (2009/07/25)
The alkylation of amines by alcohols has been achieved using 0.5 mol percent [Ru(p-cymene)CI2]2 with the bidentate phosphines dppf or DPEphos as the catalyst. Primary amines have been converted into secondary amines, and secondary amines into tertiary amines, including the syntheses of Piribedil, Tripelennamine, and Chlorpheniramine. A/-Heterocyclization reactions of primary amines are reported, as well as alkylation reactions of primary sulfonamides. Secondary alcohols requiremore forcing conditions than primary alcohols but are still effective a lkylating agents in the presence of this catalyst.
A base-catalyzed domino-isomerization-hydroamination reaction - A new synthetic route to amphetamines
Hartung, Christian G.,Breindl, Claudia,Tillack, Annegret,Beller, Matthias
, p. 5157 - 5162 (2007/10/03)
An efficient synthesis of pharmaceutically interesting amphetamines by a base-catalyzed domino-isomerization- hydroamination reaction is presented. Starting from allylbenzene and various primary or secondary amines, the basic structural pattern of amphetamines is synthesized directly in yields of up to 91% in the presence of catalytic amounts of n-butyllithium. (C) 2000 Elsevier Science Ltd.
Aminolysis of derivatives of trans-3-phenylglycidic acid, V: Distinction between N-substituted derivatives of 3-phenylserine and 3-phenylisoserine
Tack,Lehmann,Zymalkowski
, p. 138 - 147 (2007/10/04)
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