331942-47-3

Basic information

• Product Name: 2-(2-FURYL)BENZOIC ACID
• Synonyms: 2-FURAN-2-YL-BENZOIC ACID;2-(2-FURYL)BENZOIC ACID;AKOS BAR-0071;RARECHEM AL BO 2307;VITAS-BB TBB000329;2-Fur-2-ylbenzoic acid;2-(2-Carboxyphenyl)furan
• CAS NO: 331942-47-3
• Molecular Formula: C₁₁H₈O₃
• Molecular Weight: 188.18
• Mol File: 331942-47-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 313.5 °C at 760 mmHg
• Flash Point: 143.4 °C
• Appearance: /
• Density: 1.254 g/cm³
• Vapor Pressure: 0.00021mmHg at 25°C
• Refractive Index: 1.581
• CAS DataBase Reference: 2-(2-FURYL)BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-FURYL)BENZOIC ACID(331942-47-3)
• EPA Substance Registry System: 2-(2-FURYL)BENZOIC ACID(331942-47-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 331942-47-3(Hazardous Substances Data)

Usage

General Description

2-(2-Furyl)benzoic acid is a chemical compound with the molecular formula C13H10O4. It is a derivative of benzoic acid and contains a furan ring. 2-(2-FURYL)BENZOIC ACID is commonly used in the synthesis of pharmaceuticals and in research as a building block for organic chemistry. It has also been studied for its potential anti-inflammatory and antioxidant properties. 2-(2-Furyl)benzoic acid can be synthesized from furan and benzoic acid through various chemical reactions. It is a white to off-white crystalline powder with a slightly sweet, floral odor and is sparingly soluble in water.

InChI:InChI=1/C11H8O3/c12-11(13)9-5-2-1-4-8(9)10-6-3-7-14-10/h1-7H,(H,12,13)

Upstream product

• 610-97-9 o-iodo-methyl-benzoic acid 
• 342-54-1 2-(methoxycarbonyl)benzenediazonium tetrafluoroborate 
• 134-20-3 2-carbomethoxyaniline 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 39732-01-9 2-(2-furyl)benzoic acid methyl ester 

Downstream Products

• 299442-23-2 o-(5-formyl-2-furyl)benzonitrile 
• 155395-45-2 2-(furan-2-yl)benzonitrile 
• 39732-01-9 2-(2-furyl)benzoic acid methyl ester 
• 1215172-73-8 2-(furan-2-yl)benzoyl chloride 
• 1092503-07-5 C₂₈H₂₄Cl₂N₄O₃ 
• 897446-32-1 N-(2-aminophenyl)-2-furan-2-ylbenzamide 

Relevant articles and documents

Palladium-catalyzed intramolecular aromatic C-H acylation of 2-arylbenzoyl fluorides

The catalytic intramolecular cyclization of acyl fluorides using a Pd(OAc)2/PCy3 system is described. A wide range of 2-arylbenzoyl fluoride derivatives can be used as fluorenone precursors and the reaction proceeds via an intramolecular coupling between aromatic C-H bonds with acyl C-F bonds. The reaction can be applied to the synthesis of indenofluorenedione derivatives and to the construction of other molecules with fivemembered rings.

Synthesis and biological evaluation of benzimidazole derivatives as potent AMP-activated protein kinase activators

Design, synthesis and structure-activity relationships of benzimidazole derivatives as activators of the AMP-activated protein kinase (AMPK) are presented in this paper. AMPK is the central component of a protein kinase cascade that plays a key role in the regulation of energy balance. Once activated, AMPK initiates a series of responses that are aimed at restoring the energy balance of the cell and recent studies have indicated that AMPK plays an important role in regulation of the whole-body energy metabolism. The following study based on the lead compound S27847 involved modification of three regions of this compound. Preliminary structure-activity relationships are being described.