331947-44-5

Basic information

• Product Name: (S)-(-)-Tolvaptan
• Synonyms: (S)-(-)-Tolvaptan
• CAS NO: 331947-44-5
• Molecular Formula: C₂₆H₂₅ClN₂O₃
• Molecular Weight: 448.9413
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 331947-44-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: (S)-(-)-Tolvaptan(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-Tolvaptan(331947-44-5)
• EPA Substance Registry System: (S)-(-)-Tolvaptan(331947-44-5)

Safety Data

• Hazardous Substances Data: 331947-44-5(Hazardous Substances Data)

Usage

Description

(S)-(-)-Tolvaptan, an enantiomer of Tolvaptan, is a selective and competitive antagonist of the arginine vasopressin V2 receptor. It plays a crucial role in regulating water reabsorption in the kidneys and is instrumental in managing various medical conditions related to water balance in the body.

Uses

Used in Pharmaceutical Industry:
(S)-(-)-Tolvaptan is used as a therapeutic agent for the treatment of hyponatremia, a condition characterized by low blood sodium levels. It is particularly effective in patients with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH), as it helps to regulate the balance of water in the body and alleviate the symptoms associated with these conditions.

Upstream product

• 137973-76-3 MOP-21826 
• 331947-51-4 (S)-7-chloro-5-methoxymethyloxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 193686-73-6 (S)-7-chloro-5-hydroxy-1-(p-toluenesulfonyl)-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 331947-54-7 (S)-7-chloro-5-methoxymethyloxy-2,3,4,5-tetrahydro-1H-1-benzazepine 
• 331947-57-0 (S)-7-chloro-5-methoxymethyloxy-1-[2-methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine 

Relevant articles and documents

Efficient biosynthesis of enantiopure tolvaptan by utilizing alcohol dehydrogenase-catalyzed enantioselective reduction

Using whole cells of Escherichia coli co-expressing alcohol dehydrogenase (PsADH) and formate dehydrogenase (CpFDH) in a biphasic aqueous-soybean oil system is shown to be an efficient method for the biosynthesis of enantiopure tolvaptan. In this system, (S)-tolvaptan with an optical purity of 99.5% and a bioconversion efficiency of 86.1% was achieved.

Practical synthesis of both enantiomers of vasopressin V2 receptor antagonist OPC-41061 using the catalytic asymmetric hydrogenation

The optically active enantiomers of 7-chloro-5-hydroxy-1-[2methyl-4-(2-methylbenzoylamino)benzoyl]-2,3,4,5- tetrahydro-1H-1-benzazepine (OPC-41061, 1) were enantioselectively synthesized. The asymmetric transfer hydrogenation of the ketone (2), which is t