331963-11-2

Basic information

• Product Name: butyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate
• Synonyms: butyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate
• CAS NO: 331963-11-2
• Molecular Formula: C27H32N2O5
• Molecular Weight: 464.55338
• Mol File: 331963-11-2.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: butyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: butyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate(331963-11-2)
• EPA Substance Registry System: butyl 4-{[(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)carbonyl]amino}benzoate(331963-11-2)

Safety Data

• Hazardous Substances Data: 331963-11-2(Hazardous Substances Data)

Upstream product

• 94-25-7 4-amino-benzoic acid butyl ester 
• 52851-59-9 1-hexyl-3-ethoxycarbonyl-4-hydroxy-2(1H)-quinolinone 
• 4746-32-1 N-hexylaniline 

Relevant articles and documents

Design, synthesis and biological characterization of a new class of osteogenic (1H)-quinolone derivatives

Smoothened (Smo) is the signal transducer of the Hedgehog (Hh) pathway and its stimulation is considered a potential powerful tool in regenerative medicine to treat severe tissue injuries. Starting from GSA-10, a recently reported Hh activator acting on Smo, we have designed and synthesized a new class of quinolone-based compounds. Modification and decoration of three different portions of the original scaffold led to compounds able to induce differentiation of multipotent mesenchymal cells into osteoblasts. The submicromolar activity of several of these new quinolones (0.4–0.9?μM) is comparable to or better than that of SAG and purmorphamine, two reference Smo agonists. Structure-activity relationships allow identification of several molecular determinants important for the activity of these compounds.