332-42-3

Basic information

• Product Name: 1-(2-BROMOETHYL)-4-FLUOROBENZENE
• Synonyms: 1-FLUORO-4-(2-BROMOETHYL)BENZENE;1-BROMO-2-(4-FLUOROPHENYL)ETHANE;1-(2-BROMOETHYL)-4-FLUOROBENZENE;2-(4-FLUOROPHENYL)ETHYL BROMIDE;4-FLUORO-1-(2-BROMOETHYL)BENZENE;4-FLUOROPHENETHYL BROMIDE;1-(2-Bromoethyl)-4-fluoroBenzene,4-FluorophenethylBromide;1-Bromo-2-(4-fluorophenyl)ethane 97%
• CAS NO: 332-42-3
• Molecular Formula: C₈H₈BrF
• Molecular Weight: 203.05
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Fluorine series
• Mol File: 332-42-3.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 100-104 °C15 mm Hg(lit.)
• Flash Point: 200 °F
• Appearance: Clear colorless to light yellow or white to pale yellow/Liquid or Low Melting Solid
• Density: 1.4498 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.534(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-(2-BROMOETHYL)-4-FLUOROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BROMOETHYL)-4-FLUOROBENZENE(332-42-3)
• EPA Substance Registry System: 1-(2-BROMOETHYL)-4-FLUOROBENZENE(332-42-3)

Safety Data

• Hazard Codes: Xn,N
• Statements: 22-51/53
• Safety Statements: 61
• RIDADR: UN 3082 9 / PGIII
• WGK Germany: 2
• Hazardous Substances Data: 332-42-3(Hazardous Substances Data)

Usage

Chemical Properties

Clear slightly yellow liquid

Uses

An intermediate in the production of protein A mimetics, serotonin antagonists, and other CNS agents

Upstream product

• 6529-53-9 1-(2-bromoethyl)-4-chlorobenzene 
• 90867-08-6 4-Fluoro-α-ethylbenzenium ion 
• 405-99-2 para-fluorostyrene 
• 70931-33-8 1-[2-(4-fluorophenyl)-ethyl]-piperazine 
• 70931-13-4 11-chloro-7-fluoro-2-isopropyl-10,11-dihydrodibenzothiepin 
• 7589-27-7 2-(4-Fluorophenyl)ethanol 
• 497-19-8 sodium carbonate 
• 7789-60-8 phosphorus tribromide 
• 352-13-6 4-flourophenylmagnesium bromide 
• 405-50-5 p-Fluorophenylacetic acid 

Downstream Products

• 70931-36-1 1-ethoxycarbonyl-4-<2-(4-fluorophenyl)ethyl>piperazine 
• 6529-53-9 1-(2-bromoethyl)-4-chlorobenzene 
• 90867-08-6 4-Fluoro-α-ethylbenzenium ion 
• 459-31-4 3-(4-fluorophenyl)propanoic acid 
• 61440-42-4 p-[(p-Fluorophenethyl)amino]benzoic Acid 
• 54540-69-1 2(3,5-Dimethoxyphenyl)-3-Methyl-5-(p-Fluorophenyl)Pentane 
• 89326-70-5 1-bromo-4-(4-fluorophenyl)-butane 
• 134069-53-7 1-oxa-2-oxo-3-benzyl-4-methylene-8-[2-(4-fluorophenyl)ethyl]-3,8-diazaspiro[4,5]decane 
• 252364-42-4 (+/-)-α-[2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl]-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanone 
• 252364-41-3 [2-methoxy-3-[(1,1-dimethylethyldiphenylsilyl)oxy]phenyl][1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl]methanone 
• 1446307-97-6 (3R)-1-(4-fluorophenethyl)-3-(2-phenyl-2-(piperidinium-1-yl)acetoxy)-1-azoniabicyclo[2.2.2]octane di(trifluoroacetate) 
• 70931-34-9 1-(7-fluoro-2-isopropyl-10,11-dihydrodibenzothiepin-11-yl)-4-(2-(4-fluorophenyl)ethyl)piperazine 
• 164179-52-6 1-iodo-2-(4-fluorophenyl)ethane 
• 129254-86-0 1-(4-fluorophenyl)-3-(pyridin-4-yl)-butane 

Relevant articles and documents

Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons

A stereoselective hydroxylation and enantioselective dehalogenation cascade reaction was developed for the synthesis of optically active β-haloalcohols from halohydrocarbons. This cascade system employed P450 and halohydrin dehalogenase as two compatible biocatalysts, allowing a straightforward, greener and efficient access to β-halohydrins with excellent enantioselectivities (98-99%).

Spiroalkene carboxamide derivatives and their use as chemokine receptor modulators

The present invention is directed to compounds of Formula (I) below, which are antagonists to the chemoattractant cytokine receptor 2 (CCR2), and/or 5 (CCR5), pharmaceutical compositions, and methods for use thereof.

3-Hydroxypyrimidine-2,4-diones as an Inhibitor Scaffold of HIV Integrase

Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). Inhibitors with a novel structure core are essential for combating resistance associated with known IN inhibitors (INIs). We have previously disclosed a novel dual inhibitor scaffold of HIV IN and reverse transcriptase (RT). Here we report the complete structure-activity relationship (SAR), molecular modeling, and resistance profile of this inhibitor type on IN inhibition. These studies support an antiviral mechanism of dual inhibition against both IN and RT and validate 3-hydroxypyrimidine-2,4-diones as an IN inhibitor scaffold.