33261-95-9 Usage
Description
(17beta)-3,3-[ethylenebis(oxy)]-17-hydroxyandrost-5-ene-17-carbonitrile, commonly known as ethinylestradiol, is a synthetic estrogen derivative that plays a significant role in various medical applications. (17beta)-3,3-[ethylenebis(oxy)]-17-hydroxyandrost-5-ene-17-carbonitrile is characterized by its ability to mimic the effects of natural estrogen in the body, which allows it to regulate the menstrual cycle, prevent ovulation, and address specific health conditions.
Uses
Used in Hormonal Contraceptives:
Ethinylestradiol is used as an active ingredient in hormonal contraceptives, where it helps to prevent ovulation and thus, the likelihood of pregnancy. Its inclusion in birth control pills or patches ensures a controlled release of the hormone, providing effective contraception.
Used in Hormone Replacement Therapy (HRT):
In the context of menopause, ethinylestradiol is utilized in hormone replacement therapy to alleviate symptoms associated with the hormonal changes that occur during this phase. It helps to manage hot flashes, night sweats, and vaginal dryness, improving the overall quality of life for menopausal women.
Used in Treatment of Acne:
Due to its ability to regulate hormonal levels, ethinylestradiol is also used in the treatment of acne, particularly in women. It helps to reduce the production of sebum, which is a common cause of acne breakouts, leading to clearer and healthier skin.
Used in Oncology:
Ethinylestradiol has applications in the treatment of certain types of breast cancer. Its estrogenic effects can be leveraged to inhibit the growth of hormone-sensitive tumors, making it a valuable component in cancer management strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 33261-95-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,2,6 and 1 respectively; the second part has 2 digits, 9 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 33261-95:
(7*3)+(6*3)+(5*2)+(4*6)+(3*1)+(2*9)+(1*5)=99
99 % 10 = 9
So 33261-95-9 is a valid CAS Registry Number.
33261-95-9Relevant articles and documents
Synthesis and characterization by 1H and 13C nuclear magnetic resonance spectroscopy of 17 alpha-cyano, 17 alpha-aminomethyl, and 17 alpha-alkylamidomethyl derivatives of 5 alpha-dihydrotestosterone and testosterone.
Mappus,Chambon,Rolland de Ravel,Grenot,Cuilleron
, p. 603 - 620 (1997)
17 alpha-Aminomethyl, 17 alpha-acetamidomethyl, and 17 alpha-hemiglutaramidomethyl derivatives of dihydrotestosterone and testosterone have been prepared by hydrocyanation of 3,3'-(ethylenedioxy)-5 alpha-androstan-17-one and 3,3'-ethylenedioxyandrost-5-en-17-one, reduction of the corresponding acetylated 17 alpha-cyanohydrins with lithium aluminium hydride, and acylation of the resulting 17 alpha-aminomethyl derivatives with either acetic anhydride or the mono acid chloride of glutaric acid mono methyl ester. Saponification of the 17 alpha-hemiglutaramidomethyl methyl esters gave the corresponding hemiglutaramido derivatives, while acid hydrolysis of the 3-ethylene ketal group of 17 alpha-acetamidomethyl and 17 alpha-hemiglutaramidomethyl derivatives regenerated the 3-oxo and 3-oxo-4-ene functions. The 17 alpha-configuration of 17-substituted steroids was determined by 1H and 13C NMR and confirmed by comparing with NMR data for 17 alpha- and 17 beta-cyano-17-hydroxyandrost-4-en-3-one, 17 beta-cyano-3,3'-(ethylenedioxy)androst-5-en-17-ol, 17 alpha-alkynyl, and 17 alpha-hexanoic derivatives of dihydrotestosterone and testosterone, of known 17-configurations. Several ambiguous assignments of 13C NMR signals of 17 alpha-substituted steroids and unsubstituted 17 beta-hydroxy or 17-oxo precursors have been resolved using steroid analogs deuterated at positions C5-7, or C16 for androstane derivatives, and at positions C6-7, or C7 for androstene derivatives. 17 alpha-Aminomethyl and 17 alpha-alkylamidomethyl derivatives of dihydrotestosterone and testosterone are useful intermediates for the access to potential ligands of androgen-binding proteins necessary for affinity chromatography purification or affinity-labeling experiments.
