33280-23-8

Basic information

• Product Name: N-(4-chlorophenyl)-N-methyl-2-bromoacetamide
• Synonyms: N-(4-chlorophenyl)-N-methyl-2-bromoacetamide
• CAS NO: 33280-23-8
• Molecular Weight: 262.534
• Mol File: 33280-23-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-(4-chlorophenyl)-N-methyl-2-bromoacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-N-methyl-2-bromoacetamide(33280-23-8)
• EPA Substance Registry System: N-(4-chlorophenyl)-N-methyl-2-bromoacetamide(33280-23-8)

Safety Data

• Hazardous Substances Data: 33280-23-8(Hazardous Substances Data)

Upstream product

• 13094-51-4 bromoacetic anhydride 
• 932-96-7 N-methyl(p-chloroaniline) 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 1337537-43-5 N-(4-chlorophenyl)-N-methyl-2-(4-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazolo[3,4-b]quinolin-1-yl)acetamide 
• 1337537-60-6 N-(4-chlorophenyl)-N-methyl-2-(4-methyl-3-oxo-2-phenyl-2H-pyrazolo[3,4-b]quinolin-9(3H)-yl)acetamide 
• 1337537-62-8 N-(4-chlorophenyl)-2-[2-(4-fluorophenyl)-4-methyl-3-oxo-2H-pyrazolo[3,4-b]quinolin-9(3H)-yl]-N-methylacetamide 
• 1337537-53-7 N-(4-chlorophenyl)-2-[2-(4-fluorophenyl)-4-methyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]quinolin-1-yl]-N-methylacetamide 
• 1337537-56-0 N-(4-chlorophenyl)-2-[2-(4-chlorophenyl)-4-methyl-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-b]quinolin-1-yl]-N-methylacetamide 
• 59852-31-2 4-chloro-benzylamine; hydrobromide 
• 59852-32-3 (4-methoxyphenyl)methanaminium bromide 
• 37488-40-7 benzylamine hydrobromide 
• 130191-64-9 p-methylbenzylamine hydrobromide 
• 60434-13-1 5-chloro-1-methylindoline-2, 3-dione 
• 41192-33-0 5-chloro-1-methylindolin-2-one 
• 1384520-99-3 2-diazo-N-(4-chlorophenyl)-N-methylacetamide 

Relevant articles and documents

Synthesis of Oxindole Derivatives via Intramolecular C–H Insertion of Diazoamides Using Ru(II)-Pheox Catalyst

This work presented the efficient intramolecular aromatic C–H insertion of diazoacetamide. The 1a–1o diazo compounds (except for 1k) were converted into their corresponding oxindoles via an intramolecular C–H insertion reaction in the presence of a Ru catalyst. The Ru-Pheox catalyst was shown to be highly efficient in this transformation in terms of the regioselectivity, producing the desired products in excellent yield (99%). The efficiency of the Ru catalyst reached 580 (TON) and 156 min?1 (TOF).

Transition-Metal-Free Fluoroarylation of Diazoacetamides: A Complementary Approach to 3-Fluorooxindoles

An efficient transition-metal-free fluoroarylation reaction of N-aryl diazoacetamides with NFSI (N-fluorobenzenesulfonimide) is described. This reaction directly provides 3-fluorooxindole derivatives in yields of 67-93% with high selectivity via a carbene

Synthesis and structure-activity relationship studies in translocator protein ligands based on a pyrazolo[3,4-b]quinoline scaffold

As a further development of our large program focused on the medicinal chemistry of translocator protein [TSPO (18 kDa)] ligands, a new class of compounds related to alpidem has been designed using SSR180575, emapunil, and previously published pyrrolo[3,4-b]quinoline derivatives 9 as templates. The designed compounds were synthesized by alkylation of the easily accessible 4-methyl-2-phenyl-1H-pyrazolo[3,4-b]quinolin-3(2H)-one derivatives 13-15 with the required bromoacetamides. Along with the expected 2-(4-methyl-3-oxo-2- phenyl-2,3-dihydro-1H-pyrazolo[3,4-b]quinolin-1-yl)acetamide derivatives 10, 2-(4-methyl-3-oxo-2-phenyl-2H-pyrazolo[3,4-b]quinolin-9(3H)-yl)acetamide isomers 11 were isolated and characterized. The high TSPO affinity shown by new pyrazolo[3,4-b]quinoline derivatives 10 and especially 11 leads the way to further expand the chemical diversity in TSPO ligands and provides new templates and structure-affinity relationship data potentially useful in the design of new anxiolytic and neuroprotective agents.