33282-22-3

Basic information

• Product Name: 5-(4-CHLOROPHENYL)ISOXAZOLE-3-CARBOXYLIC ACID
• Synonyms: TIMTEC-BB SBB006946;5-(4-CHLOROPHENYL)ISOXAZOLE-3-CARBOXYLIC ACID;5-(4-CHLOROPHENYL)ISOXAZOLE-3-CARBOXYLI&;3-isoxazolecarboxylic acid, 5-(4-chlorophenyl)-;Albb-009766;5-(4-Chlorophenyl)isoxazole-3-carboxylic acid 97%
• CAS NO: 33282-22-3
• Molecular Formula: C₁₀H₆ClNO₃
• Molecular Weight: 223.61
• Product Categories: Halogenated Heterocycles;Heterocyclic Building Blocks;Isoxazoles;IsoxazolesBuilding Blocks;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 33282-22-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 200.0 °C (dec.)(lit.)
• Boiling Point: 457.3°Cat760mmHg
• Flash Point: 230.4°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.71E-09mmHg at 25°C
• Refractive Index: 1.599
• Storage Temp.: 2-8°C
• PKA: 3.24±0.10(Predicted)
• CAS DataBase Reference: 5-(4-CHLOROPHENYL)ISOXAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-CHLOROPHENYL)ISOXAZOLE-3-CARBOXYLIC ACID(33282-22-3)
• EPA Substance Registry System: 5-(4-CHLOROPHENYL)ISOXAZOLE-3-CARBOXYLIC ACID(33282-22-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 33282-22-3(Hazardous Substances Data)

Usage

General Description

5-(4-Chlorophenyl)isoxazole-3-carboxylic acid is a chemical compound with the molecular formula C10H6ClNO3. It is a derivative of isoxazole and contains a carboxylic acid functional group. 5-(4-CHLOROPHENYL)ISOXAZOLE-3-CARBOXYLIC ACID is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and bioactive molecules. It exhibits potential biological activities and is of interest in medicinal chemistry research. The presence of the chlorophenyl group in the structure imparts specific properties and reactivity to the compound, making it a valuable tool for drug discovery and development. Additionally, 5-(4-chlorophenyl)isoxazole-3-carboxylic acid may also have applications in other scientific fields such as agrochemicals and materials science.

InChI:InChI=1/C10H6ClNO3/c11-7-3-1-6(2-4-7)9-5-8(10(13)14)12-15-9/h1-5H,(H,13,14)

Upstream product

• 81282-12-4 ethyl 5-(4-chlorophenyl)isoxazole-3-carboxylate 
• 86425-09-4 4-(4-chlorophenyl)but-3-en-2-one oxime 
• 3160-40-5 4-(4-chlorophenyl)-3-buten-2-one 
• 65356-49-2 ethyl 4-(4-chlorophenyl)-2-hydroxy-4-oxobut-2-enoate 
• 99-91-2 para-chloroacetophenone 

Downstream Products

• 50872-45-2 C₁₀H₅Cl₂NO₂ 
• 1105633-27-9 C₂HF₃O₂*C₁₈H₁₂ClN₃O₂ 
• 1292281-82-3 N-(3-(5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-ylcarbamoyl)-4-methylphenyl)-5-(4-chlorophenyl)isoxazole-3-carboxamide 
• 1292281-83-4 N-(4-((5-amino-1-(4-methoxybenzyl)-1H-pyrazol-4-yl)carbamoyl)-3-methylphenyl)-5-(4-chlorophenyl)isoxazole-3-carboxamide 
• 1334687-03-4 5-(4-chlorophenyl)-N,N-di-n-hexylisoxazole-3-carboxamide 
• 1334687-02-3 5-(4-chlorophenyl)-N,N-di-n-propylisoxazole-3-carboxamide 
• 1391626-08-6 (3S,6S)-4-(5-(4-chlorophenyl)isoxazole-3-carbonyl)-3,6-diisobutylpiperazin-2-one 

Relevant articles and documents

Novel N-benzylpiperidine derivatives of 5-arylisoxazole-3-carboxamides as anti-Alzheimer's agents

The complex pathophysiology of Alzheimer's disease (AD) has prompted researchers to develop multitarget-directed molecules to find an effective therapy against the disease. In this context, a novel series of N-(1-benzylpiperidin-4-yl)-5-arylisoxazole-3-ca

Design and Synthesis of Novel Arylisoxazole-Chromenone Carboxamides: Investigation of Biological Activities Associated with Alzheimer's Disease

A novel series of hybrid arylisoxazole-chromenone carboxamides were designed, synthesized, and evaluated for their cholinesterase (ChE) inhibitory activity based on the modified Ellman's method. Among synthesized compounds, 5-(3-nitrophenyl)-N-{4-[(2-oxo-

1,2,3-Triazole-isoxazole based acetylcholinesterase inhibitors: Synthesis, biological evaluation and docking study

In this work, a series of derivatives containing 1,2,3-triazole and isoxazole were synthesized. All of them were evaluated as novel dual AChE inhibitors. Most of synthesized compounds showed moderate to good inhibitory potency toward AChE. Among them, N-(