33284-17-2

Basic information

• Product Name: Ethanone, 2,2,2-trifluoro-1-(2-pyridinyl)- (9CI)
• Synonyms: Ethanone, 2,2,2-trifluoro-1-(2-pyridinyl)- (9CI);2-trifluoroacetypyridine;2,2,2-trifluoro-1-(pyridin-2-yl)ethanone;2-(Trifluoroacetyl)pyridine;2-(Trifluoroacetyl)pyridine (contains gem-diol);Ethanone, 2,2,2-trifluoro-1-(2-pyridinyl)-;2,2,2-trifluoro-1-(2-pyridinyl)Ethanone;2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-one
• CAS NO: 33284-17-2
• Molecular Formula: C₇H₄F₃NO
• Molecular Weight: 175.1079696
• Product Categories: ACETYLHALIDE
• Mol File: 33284-17-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 172.9 °C at 760 mmHg
• Flash Point: 58.4 °C
• Appearance: /
• Density: 1.341 g/cm³
• Vapor Pressure: 1.3mmHg at 25°C
• Refractive Index: 1.446
• Storage Temp.: 2-8°C
• PKA: 0.95±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 2,2,2-trifluoro-1-(2-pyridinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2,2-trifluoro-1-(2-pyridinyl)- (9CI)(33284-17-2)
• EPA Substance Registry System: Ethanone, 2,2,2-trifluoro-1-(2-pyridinyl)- (9CI)(33284-17-2)

Safety Data

• Hazardous Substances Data: 33284-17-2(Hazardous Substances Data)

Usage

General Description

Ethanone, 2,2,2-trifluoro-1-(2-pyridinyl)- (9CI) is a chemical compound with the molecular formula C8H5F3NO. It is a derivative of 2-pyridinecarboxaldehyde and is known for its trifluoromethyl ketone functionality. Ethanone, 2,2,2-trifluoro-1-(2-pyridinyl)- (9CI) may be used in various chemical and pharmaceutical applications, including as a reagent in organic synthesis and as an intermediate in the production of pharmaceuticals. It is important to handle and store this compound in accordance with proper safety guidelines due to its potential hazards and reactivity.

InChI:InChI=1/C7H4F3NO/c8-7(9,10)6(12)5-3-1-2-4-11-5/h1-4H

Upstream product

• 107040-75-5 2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-ol 
• 1121-60-4 pyridine-2-carbaldehyde 

Downstream Products

• 1184723-77-0 3-phenyl-1-(trifluoromethyl)imidazo[1,5-a]pyridine 
• 1616797-52-4 3-trifluoromethyl-[1,2,3]triazolo[1,5-a]pyridine 
• 107040-75-5 2,2,2-trifluoro-1-(pyridin-2-yl)ethan-1-ol 
• 80483-84-7 (R)-2,2,2-trifluoro-1-(pyridin-2-yl)ethanol 
• 80483-85-8 (S)-2,2,2-trifluoro-1-(pyridin-2-yl)ethanol 

Relevant articles and documents

Catalytic Oxidation of Alcohols Using a 2,2,6,6-Tetramethylpiperidine-N-hydroxyammonium Cation

The oxidation of alcohols to aldehydes, ketones, and carboxylic acids is reported using 2,2,6,6-tetramethylpiperidine-4-acetamido-hydroxyammonium tetrafluoroborate as a catalyst in conjunction with sodium hypochlorite pentahydrate as a terminal oxidant. The reaction is generally complete within 30–120 min using an acetonitrile/water mix as the solvent, and no additives are required. Product yields are good to excellent and of particular note is that the methodology can be used to access aryl α-trifluoromethyl ketones.

Organocatalytic Aerobic Oxidation of α-Fluoroalkyl Alcohols to Fluoroalkyl Ketones at Room Temperature

The organocatalytic aerobic oxidation of electron-deficient α-fluoroalkyl alcohols at room temperature is described. The resulting fluoroalkyl ketones are versatile synthetic intermediates for a variety of fluorine-containing molecules. This otherwise difficult transformation has now been accomplished by the reaction of α-fluoroalkyl alcohols with N-oxyl radicals, catalytically generated from 9-azabicyclo[3.3.1]nonan-3-one N-oxyl/nitrogen oxide (keto-ABNO/NOx) and oxygen in acetic acid (AcOH), affording the corresponding fluoroalkyl ketones in high yield. This operationally simple reaction can be performed under mild conditions, and was applied to a wide range of alcohols (20 examples), thus demonstrating a high functional group tolerance. Moreover, a modified one-pot protocol based on this method was able to convert an aldehyde to a trifluoromethyl ketone on a gram scale.

Superelectrophiles and the effects of trifluoromethvl substituents

-