332882-82-3

Basic information

• Product Name: 1,3-bis(t-butoxycarbonyl)guanidine
• CAS NO: 332882-82-3
• Molecular Weight: 259.305
• Mol File: 332882-82-3.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: 1,3-bis(t-butoxycarbonyl)guanidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-bis(t-butoxycarbonyl)guanidine(332882-82-3)
• EPA Substance Registry System: 1,3-bis(t-butoxycarbonyl)guanidine(332882-82-3)

Safety Data

• Hazardous Substances Data: 332882-82-3(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 50-01-1 guanidine hydrochloride 
• 107819-90-9 1,3-bis(tert-butoxycarbonyl)-2-methyl-2-thiopseudourea 
• 322474-21-5 N,N'-bis-Boc-S-methyl-isothiourea 
• 867-44-7 S-Methylisothiourea sulfate 
• 145013-05-4 tert-butyl N-({[(tert-butoxy)carbonyl]amino}methanethioyl)carbamate 

Downstream Products

• 870193-64-9 [amino-(3-benzylureido)-methylene]carbamic acid tert-butyl ester 
• 1000875-21-7 N,N''-bis(tert-butoxycarbonyl)-N-(3-trimethylstannylbenzyl)guanidine 
• 1428427-37-5 C₆₄H₇₃N₇O₆ 
• 1428427-65-9 C₆₄H₇₃N₇O₆ 
• 1428427-79-5 C₆₄H₇₃N₇O₆ 
• 1428427-86-4 C₆₄H₇₃N₇O₆ 
• 1428428-03-8 C₆₄H₇₃N₇O₆ 
• 1428439-38-6 C₆₄H₇₃N₇O₆ 
• 1428428-22-1 C₆₄H₇₃N₇O₆ 
• 1428428-15-2 C₆₄H₇₃N₇O₆ 
• 68656-33-7 N-1-imidamidyl-N-3-phenylurea hydrochloride 
• 1295650-25-7 N-[3-(4-benzyloxy-phenyl)-isoxazol-5-ylmethyl]-N,N'-di-Boc-guanidine 
• 1131843-91-8 C₃₈H₅₇N₅O₁₁ 
• 757952-46-8 N₁,N₂-bis(tert-butyloxycarbonyl)-N₁-(1-phenyl-2-propenyl)guanidine 

Relevant articles and documents

Studies on the synthesis of peptides containing dehydrovaline and dehydroisoleucine based on copper-mediated enamide formation

The preparation of peptide fragments containing dehydrovaline and dehydroisoleucine moieties present in the antibiotic myxovalargin is reported. Peptide formation is based on a copper-mediated C-N cross-coupling protocol between an acyl amide and a peptidic vinyl iodide. The presence of a neighboring arginine in the vinyl iodide posed a challenge with respect to the choice of the protecting group and the reaction conditions. It was found that ornithine - a suitable precursor - is better suited than arginine for achieving good yields for the C-N cross-coupling reaction. The optimized conditions were utilized for the synthesis of peptides 32, 33, 39 and 40 containing a neighboring ornithine as well as for the tripeptide 44 containing dehydroisoleucine with the correct stereochemistry.

Tailoring the Physicochemical Properties of Antimicrobial Peptides onto a Thiazole-Based γ-Peptide Foldamer

Antimicrobial peptides (AMPs) are amphipathic molecules displaying broad-spectrum bactericidal activity, providing opportunities to develop a new generation of antibiotics. However, their use is limited either by poor metabolic stability or by high hemolytic activity. We herein addressed the potential of thiazole-based γ-peptide oligomers named ATCs as tunable scaffolds to design polycationic AMP mimetics. Knowing the side chain distribution along the backbone, we rationally designed facially amphiphilic sequences with bactericidal effect in the micromolar range. Since no hemolytic activity was detected up to 100 μM, this class of compounds has shown the potential for therapeutic development.

ANTIBACTERIAL THERAPEUTICS AND PROPHYLACTICS

The present disclosure relates generally to novel molecules, compositions, and formulations for treatment of bacterial infections in general and more specifically to bacterial infections with antibiotic resistant pathogens.