33304-33-5 Usage
General Description
(1H-pyrrol-2-ylmethylidene)propanedioic acid, also known as pyrrole-2-carboxylic acid, is a chemical compound with the molecular formula C8H7NO4. It is a derivative of pyrrole, a five-membered aromatic heterocycle. (1H-pyrrol-2-ylmethylidene)propanedioic acid is a carboxylic acid with a pyrrole ring attached to the α-carbon of the propanedioic acid group. It has potential applications in pharmaceutical and material science due to its unique structure and properties. Additionally, (1H-pyrrol-2-ylmethylidene)propanedioic acid may be used as a building block for the synthesis of other related compounds with biological activity. Further research and experimentation are needed to fully explore the potential uses of this chemical.
Check Digit Verification of cas no
The CAS Registry Mumber 33304-33-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,3,0 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 33304-33:
(7*3)+(6*3)+(5*3)+(4*0)+(3*4)+(2*3)+(1*3)=75
75 % 10 = 5
So 33304-33-5 is a valid CAS Registry Number.
33304-33-5Relevant articles and documents
Toward a Scalable Synthesis and Process for EMA401, Part II: Development and Scale-Up of a Pyridine- A nd Piperidine-Free Knoevenagel-Doebner Condensation
Hardegger, Leo A.,Humair, Roger,Sidler, Eric
, p. 1756 - 1762 (2020/10/26)
During route scouting for EMA401 (1), an angiotensin II type 2 antagonist, we identified the synthesis of key amino acid intermediate 2 via its cinnamic acid derivative 3 as a streamlined option. In general, cinnamic acids can be synthesized from the corresponding aldehydes by a Knoevenagel-Doebner condensation in pyridine with piperidine as an organocatalyst. We aimed to replace both of these reagents and found novel conditions involving toluene as the solvent and morpholine as the organocatalyst. Scale-up of the process allowed the production of 25 kg of cinnamic acid 3 that was of the quality required for process development of the subsequent phenylalanine ammonia lyase-catalyzed step. The modified conditions were found to be widely applicable to alternative aldehydes and thus are of relevance to practitioners of chemical scale-up.
