33328-21-1Relevant articles and documents
Facile synthesis of S-arylisothioureas via the S-arylation of arylthioureas with aryl iodides in water
Liu, Xing,Zhu, Hui,Zhang, Shi-Bo,Cheng, Yu,Peng, Han-Ying,Dong, Zhi-Bing
, p. 3165 - 3170 (2018)
An environmentally benign, simple and highly efficient protocol for the synthesis of S-arylisothiourea derivatives has been achieved in good to excellent yields by reacting a series of aryl iodides with arylthioureas, using inexpensive CuSO4·5H2O as catalyst in water without PTC (phase transfer catalyst). The protocol features easy performance, good to excellent yields, good tolerance towards a variety of functional groups, which could be useful for the preparation of some biologically active compounds.