33332-31-9 Usage
General Description
5-Methoxy-2-chloropyrazine is a chemical compound with the formula C5H5ClN2O. It is a chlorinated pyrazine derivative that contains a methoxy group. This yellow liquid compound is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It has a wide range of applications in the field of organic synthesis, including as a building block for the preparation of various heterocyclic compounds. 5-Methoxy-2-chloropyrazine has also been studied for its potential biological and pharmacological activities, making it a valuable target for drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 33332-31-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,3,3 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 33332-31:
(7*3)+(6*3)+(5*3)+(4*3)+(3*2)+(2*3)+(1*1)=79
79 % 10 = 9
So 33332-31-9 is a valid CAS Registry Number.
InChI:InChI=1S/C5H5ClN2O/c1-9-5-3-7-4(6)2-8-5/h2-3H,1H3
33332-31-9Relevant articles and documents
Studies on Pyrazines. 29. High Regioselective Synthesis of Chloropyrazines from 3-Substituted Pyrazine 1-Oxides
Sato, Nobuhiro,Fujii, Megumi
, p. 1177 - 1180 (2007/10/02)
Reaction of 3-methoxy- or 3-chloropyrazine 1-oxides with refluxing phosphoryl chloride in the presence of amine led to a high regioselective formation of 3-substituted 2-chloropyrazines.In contrast, the use of chloroacetyl chloride instead of phosphoryl chloride enabled different regioselectivity to yield 6-substituted 2-chloropyrazines, particularly 3-methoxycarbonylpyrazine 1-oxide was almost exclusively converted into methyl 6-chloropyrazinecarboxylate under conditions without the amine.
