33332-49-9

Basic information

• Product Name: Pyrazinecarboxamide, 6-amino- (8CI,9CI)
• Synonyms: Pyrazinecarboxamide, 6-amino- (8CI,9CI);6-aMinopyrazine-2-carboxaMide
• CAS NO: 33332-49-9
• Molecular Formula: C5H6N4O
• Molecular Weight: 138.12734
• Product Categories: AMIDE
• Mol File: 33332-49-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyrazinecarboxamide, 6-amino- (8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrazinecarboxamide, 6-amino- (8CI,9CI)(33332-49-9)
• EPA Substance Registry System: Pyrazinecarboxamide, 6-amino- (8CI,9CI)(33332-49-9)

Safety Data

• Hazardous Substances Data: 33332-49-9(Hazardous Substances Data)

Upstream product

• 98-97-5 2-pyrazylcarboxylic acid 
• 23688-89-3 6-chloropyrazine-2-carboxylic acid 
• 148673-71-6 6-chloropyrazine-2-carboxylic acid chloride 
• 36070-79-8 6-chloro-pyarzine-2-carboxamide 

Relevant articles and documents

Alkylamino derivatives of pyrazinamide: Synthesis and antimycobacterial evaluation

A series of pyrazinamide derivatives with alkylamino substitution was designed, synthesized and tested for their ability to inhibit the growth of selected mycobacterial, bacterial and fungal strains. The target structures were prepared from the corresponding 5-chloro (1) or 6-chloropyrazine-2-carboxamide (2) by nucleophilic substitution of chlorine by various non-aromatic amines (alkylamines). To determine the influence of alkyl substitution, corresponding amino derivatives (1a, 2a) and compounds with phenylalkylamino substitution were prepared. Some of the compounds exerted antimycobacterial activity against Mycobacterium tuberculosis H37Rv significantly better than standard pyrazinamide and corresponding starting compounds (1 and 2). Basic structure-activity relationships are presented. Only weak antibacterial and no antifungal activity was detected.