333320-72-2

Basic information

• Product Name: N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide
• Synonyms: N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide
• CAS NO: 333320-72-2
• Molecular Formula: C₁₄H₁₄INO₄S
• Molecular Weight: 419.23473
• Mol File: 333320-72-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide(333320-72-2)
• EPA Substance Registry System: N-(4-iodophenyl)-3,4-dimethoxybenzenesulfonamide(333320-72-2)

Safety Data

• Hazardous Substances Data: 333320-72-2(Hazardous Substances Data)

Upstream product

• 23095-31-0 3,4-dimethoxybenzene-1-sulfonyl chloride 
• 540-37-4 p-aminoiodobenzene 

Downstream Products

• 501682-95-7 3-[4-(3,4-Dimethoxy-benzenesulfonylamino)-phenyl]-acrylic acid 
• 342372-36-5 PX117794 

Relevant articles and documents

Polymer-assisted, multi-step solution phase synthesis and biological screening of histone deacetylase inhibitors

The polymer-assisted solution phase synthesis (PASP) of an array of histone deacetylase (HDAc) inhibitors is described. HDAc inhibitors have considerable potential as new anti-proliferative agents. Selected compounds were shown to inhibit both human endothelial cell proliferation, and the formation of tubules (neovascularisation) in an in vitro model of angiogenesis.

Design and synthesis of a novel class of histone deacetylase inhibitors.

Histone deacetylase inhibitors (HDACs) have emerged as a novel class of antiproliferative agents. Utilizing structure-based design, the synthesis of a series of sulfonamide hydroxamic acids is described. Further optimization of this series by substitution of the terminal aromatic ring yielded HDAC inhibitors with good in vitro and in vivo activities.