333366-27-1Relevant articles and documents
Solid-phase Staudinger ligation from a novel core-shell-type resin: A tool for facile condensation of small peptide fragments
Kim, Hanyoung,Cho, Jin Ku,Aimoto, Saburo,Lee, Yoon-Sik
, p. 1149 - 1151 (2006)
Solid-phase Staudinger ligation of small peptides was performed on a novel core-shell-type resin. Solid-phase Staudinger ligation was mediated by synthetic solid-supported phosphinothiol, which was readily prepared by a straightforward synthetic route. This protocol afforded final peptide products in excellent yields and purities and thus could provide the opportunity to facilitate a simple manipulation for condensation of peptide fragments. In particular, the resulting resin could be recycled in a successful manner.
Improved solid-phase peptide synthesis method utilizing alpha-azide-protected amino acids.
Lundquist 4th.,Pelletier
, p. 781 - 783 (2007/10/03)
[structure: see text]. Pure alpha-azido acids were prepared using an efficient diazo transfer method followed by buffered workup. These building blocks were used to prepare small peptides on Wang resin by two approaches. Peptides prone to diketopiperazine formation were prepared in good yields by coupling acids to resin bound iminophosphoranes during Fmoc-Wang synthesis. The iminophosphoranes can also be hydrolyzed under neutral conditions to provide unprotected amines ready for further coupling.