3335-46-4 Usage
Description
3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine is a chemical compound characterized by the presence of a cyano group, two hydroxyl groups, and a trifluoromethyl group attached to a pyridine ring. This unique molecular structure endows it with potential applications in various fields, particularly in the development of pharmaceuticals.
Uses
Used in Pharmaceutical Industry:
3-Cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine is used as a reagent in the synthesis of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines. These synthesized compounds have the potential to be developed as antitumor agents, offering new therapeutic options for cancer treatment.
In the synthesis process, 3-cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine serves as a key building block, contributing to the formation of the desired indolyl and bisindolyl pyridine derivatives. The incorporation of the trifluoromethyl group is particularly noteworthy, as it can significantly influence the pharmacological properties of the resulting compounds, including their lipophilicity, metabolic stability, and binding affinity to target proteins. This makes 3-cyano-2,6-dihydroxy-4-(trifluoromethyl)pyridine a valuable component in the design and development of innovative antitumor drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 3335-46-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,3,3 and 5 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 3335-46:
(6*3)+(5*3)+(4*3)+(3*5)+(2*4)+(1*6)=74
74 % 10 = 4
So 3335-46-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H3F3N2O2/c8-7(9,10)4-1-5(13)12-6(14)3(4)2-11/h1H,(H2,12,13,14)
3335-46-4Relevant articles and documents
Synthesis and antitumor evaluation of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines
Jiang, Biao,Xiong, Xen-Nan,Yang, Cai-Guang
, p. 475 - 477 (2007/10/03)
A series of novel monoindolyl-4-trifluoromethylpyridines and bisindolyl-4-trifluoromethylpyridines was designed and synthesized as potential antitumor agents. They were evaluated for preliminary cytotoxic activity against P388 and A-549 cells with IC50 values. 4-Trifluoromethyl-2,6-bis[3′-(N-tosyl-6′-methoxyl-indolyl)] pyridine was identified as the most potent in this series.
