3337-62-0Relevant articles and documents
A convenient and efficient H2SO4-promoted regioselective monobromination of phenol derivatives using N-bromosuccinimide
Wu, Yong-Qi,Lu, Hai-Jia,Zhao, Wen-Ting,Zhao, Hong-Yi,Lin, Zi-Yun,Zhang, Dong-Feng,Huang, Hai-Hong
supporting information, p. 813 - 822 (2020/02/15)
A convenient, rapid H2SO4-promoted regioselective monobromination reaction with N-bromosuccinimide was developed. The desired para-monobrominated or ortho-monobrominated products of phenol derivatives were obtained in good to excellent yields with high selectivity. Regioselective chlorination and iodination were also achieved in the presence of H2SO4 using N-chlorosuccinimide and N-iodosuccinimide, respectively.
IMPROVED PROCESSES FOR THE PREPARATION OF SOFOSBUVIR AND INTERMEDIATES THEREOF
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, (2016/12/22)
The present disclosure provides new procedures and intermediates for the preparation of Sofosbuvir.
Peroxidative bromination and oxygenation of organic compounds: Synthesis, X-ray crystal structure and catalytic implications of mononuclear and binuclear oxovanadium(V) complexes containing Schiffbase ligands
Si, Tapan Kumar,Drew, Michael G.B.,Mukherjea, Kalyan Kumar
experimental part, p. 2286 - 2293 (2011/10/11)
Treatment of of (R,R)-N,N-salicylidene cyclohexane 1,2-diamine(H 2L1) in methanol with aqueous NH4VO3 solution in perchloric acid medium affords the mononuclear oxovanadium(V) complex [VOL1(MeOH)]·ClO4 (1) as deep blue solid while the treatment of same solution of (R,R)-N,N-salicylidene cyclohexane 1,2-diamine(H2L1) with aqueous solution of VOSO 4 leads to the formation of di-(μ-oxo) bridged vanadium(V) complex [VO2L2]2 (2) as green solid where HL 2 = (R,R)-N-salicylidene cyclohexane 1,2-diamine. The ligand HL 2 is generated in situ by the hydrolysis of one of the imine bonds of HL1 ligand during the course of formation of complex [VO 2L2]2 (2). Both the compounds have been characterized by single crystal X-ray diffraction as well as spectroscopic methods. Compounds 1 and 2 are to act as catalyst for the catalytic bromide oxidation and C-H bond oxidation in presence of hydrogen peroxide. The representative substrates 2,4-dimethoxy benzoic acid and para-hydroxy benzoic acids are brominated in presence of H2O2 and KBr in acid medium using the above compounds as catalyst. The complexes are also used as catalyst for C-H bond activation of the representative hydrocarbons toluene, ethylbenzene and cyclohexane where hydrogen peroxide acts as terminal oxidant. The yield percentage and turnover number are also quite good for the above catalytic reaction. The oxidized products of hydrocarbons have been characterized by GC Analysis while the brominated products have been characterized by 1H NMR spectroscopic studies.
