333746-83-1

Basic information

• Product Name: C₁₅H₁₆N₄O₂S₂
• CAS NO: 333746-83-1
• Molecular Weight: 348.45
• Mol File: 333746-83-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₆N₄O₂S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₆N₄O₂S₂(333746-83-1)
• EPA Substance Registry System: C₁₅H₁₆N₄O₂S₂(333746-83-1)

Safety Data

• Hazardous Substances Data: 333746-83-1(Hazardous Substances Data)

Upstream product

• 32519-72-5 1-(2-amino-4-methylthiazol-5-yl)-2-bromoethanone 
• 67617-98-5 (2,5-dimethoxyphenyl)thiourea 

Downstream Products

• 958974-58-8 C₂₂H₂₈N₄O₃S₂ 

Relevant articles and documents

4′-Methyl-4,5′-bithiazole-based correctors of defective ΔF508-CFTR cellular processing

The synthesis and ΔF508-CFTR corrector activity of a 148-member methylbithiazole-based library are reported. Synthetic routes were devised and optimized to generate methylbithiazole analogs in four steps. Corrector potency and efficacy were assayed using epithelial cells expressing human ΔF508-CFTR. These structure-activity data establish that the bithiazole substructure plays a critical function; eight novel methylbithiazole correctors were identified with low micromolar potencies.