3338-22-5

Basic information

• Product Name: N-propan-2-ylglycine
• Synonyms: (isopropylamino)acetic acid
• CAS NO: 3338-22-5
• Molecular Formula: C₅H₁₁NO₂
• Molecular Weight: 117.1463
• Mol File: 3338-22-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 201.3°C at 760 mmHg
• Flash Point: 75.5°C
• Density: 1.019g/cm³
• Vapor Pressure: 0.129mmHg at 25°C
• Refractive Index: 1.44
• CAS DataBase Reference: N-propan-2-ylglycine(CAS DataBase Reference)
• NIST Chemistry Reference: N-propan-2-ylglycine(3338-22-5)
• EPA Substance Registry System: N-propan-2-ylglycine(3338-22-5)

Safety Data

• Hazardous Substances Data: 3338-22-5(Hazardous Substances Data)

Usage

General Description

N-propan-2-ylglycine, also known as N-isopropylglycine, is a chemical compound with the molecular formula C5H11NO2. It is a non-proteinogenic amino acid that has a branched side chain. N-propan-2-ylglycine is used in the synthesis of pharmaceuticals, agrochemicals, and chiral catalysts due to its stereochemical properties. It can also serve as a precursor in the production of various organic compounds. The compound has potential applications in the field of medicinal chemistry and drug discovery, as it can be incorporated into peptide and protein structures to modulate their properties. N-propan-2-ylglycine may also have potential biological activities that warrant further research.

Upstream product

• 90544-82-4 (Formyl-isopropyl-amino)-acetic acid 
• 103218-05-9 (Isopropylimino)malonsaeure-diethylester 

Downstream Products

• 158831-35-7 N-carboxybenzyl-N-isopropylaminoacetic acid 
• 3183-21-9 2-(2-propylamino)acetic acid 

Relevant articles and documents

Aliphatic amino carboxylic and amino phosphonic acids, amino nitriles and amino tetrazoles as cellular rescue agents

Novel compounds of the formula I are described: wherein: R1=(CH2)mCH3 where m is 0 or an integer in the range from 1 to 16, or an alkenyl, alkynyl, alkoxy, alkylthio, or alkyl sulfinyl group having from 2 to 17 carbon atoms, R2=H, CH3 or CH2CH3 R3=H or CH3 R4=H or CH3 R5=lower alkyl having from 1 to 5 carbon atoms n is an integer in the range from 1 to 3, and X is carboxyl (COOH) or carbalkoxy (COOR5), cyano (C≡N), phosphonic acid (PO3H2), phosphonate ester (PO3[R5]2) or 5-tetrazole, and pharmaceutically acceptable salts thereof. Preferably, the compounds are optically pure enantiomers of the R- or S-configuration in which R3=R4=R5=H, R2=CH3 and R1 is a saturated aliphatic chain of one to five carbon atoms. The compounds are useful as cellular rescue agents.

Synthesis of Strombine. A New Method for Monocarboxymethylation of Primary Amines

Many common methods for monocarboxymethylation of primary amines give various amounts of dialkylated by-products.In this work the reaction of two equivalents of glyoxilic acid with representative primary aliphatic and aromatic amines, as well as with amino acids and a dipeptide, is shown to give only the N-(carboxymethyl)-N-formyl derivative of the amine under mild conditions in carboxylic acid solvents.Hydrolysis then produces the monocarboxymethylated primary amine in good to exellent overall yield.Proof that the intermediate product is not obtained via the Leuckart reaction is given.