33400-45-2

Basic information

• Product Name: ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride
• Synonyms: ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride
• CAS NO: 33400-45-2
• Molecular Formula: C15H18ClFN4O2
• Molecular Weight: 340.7804232
• EINECS: 251-496-2
• Mol File: 33400-45-2.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 434.9°Cat760mmHg
• Flash Point: 216.8°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 9.1E-08mmHg at 25°C
• CAS DataBase Reference: ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride(33400-45-2)
• EPA Substance Registry System: ethyl 2-amino-6-[[p-fluorobenzyl]amino]pyridine-3-carbamate monohydrochloride(33400-45-2)

Safety Data

• Hazardous Substances Data: 33400-45-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H17FN4O2.ClH/c1-2-22-15(21)19-12-7-8-13(20-14(12)17)18-9-10-3-5-11(16)6-4-10;/h3-8H,2,9H2,1H3,(H,19,21)(H3,17,18,20);1H

Upstream product

• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 541-41-3 chloroformic acid ethyl ester 
• 33400-49-6 2-amino-3-nitro-6-(p-fluoro-benzylamino)-pyridine 
• 140-75-0 para-fluorobenzylamine 
• 1609102-47-7 3-nitro-6-p-fluorobenzylaminopyridin-2-ylaminoformic acid tert-butyl ester 
• 75507-68-5 flupirtine maleate 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 112523-78-1 N⁶-(4-fluorobenzyl)pyridine-2,3,6-triamine 

Relevant articles and documents

Method for preparing flupirtine hydrochloride

The invention discloses a method for preparing flupirtine hydrochloride. The method comprises the following steps: adopting 2,6-dichloro-3-nitropyridine as an initial material, performing ammonolysis,substituting fluorobenzylamine, purifying, hydrogenating, performing acylation reaction, filtering, precipitating crystals and decompression drying to obtain the flupirtine hydrochloride. The methodis simple in operation, capable of simultaneously performing the hydrogenation and acylation reaction, capable of avoiding the deterioration of polyamino pyridine derivatives as far as possible, capable of titrating ethyl chloroformate without opening a kettle cover, and capable of reducing the harm on the human body.

FLUPIRTINE HYDROCHLORIDE MALEIC ACID COCRYSTAL

The invention relates to crystalline forms of flupirtine, particularly to 1:1 flupirtine hydrochloride maleic acid cocrystal. The preparation and characterization of 1:1 flupirtine hydrochloride maleic acid cocrystal is described. The invention also relates to the therapeutic use of the flupirtine hydrochloride maleic acid cocrystal to treat nervous system disorders, pain disorders, and musculoskeletal disorders and to pharmaceutical compositions containing the cocrystal.