33425-19-3

Basic information

• Product Name: 1-(4-METHOXY-PHENYL)-2-P-TOLYL-ETHANE-1,2-DIONE
• Synonyms: 1-(4-METHOXY-PHENYL)-2-P-TOLYL-ETHANE-1,2-DIONE
• CAS NO: 33425-19-3
• Molecular Formula: C₁₆H₁₄O₃
• Molecular Weight: 254.28056
• Mol File: 33425-19-3.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 422.451°C at 760 mmHg
• Flash Point: 188.488°C
• Appearance: /
• Density: 1.152g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(4-METHOXY-PHENYL)-2-P-TOLYL-ETHANE-1,2-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-PHENYL)-2-P-TOLYL-ETHANE-1,2-DIONE(33425-19-3)
• EPA Substance Registry System: 1-(4-METHOXY-PHENYL)-2-P-TOLYL-ETHANE-1,2-DIONE(33425-19-3)

Safety Data

• Hazardous Substances Data: 33425-19-3(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxy-phenyl)-2-p-tolyl-ethane-1,2-dione, also known as chalcone, is a chemical compound with a molecular formula of C18H16O3. It is commonly found in a variety of plants and fruits, such as apples, as well as in some essential oils. Chalcone is known to possess antioxidant, anti-inflammatory, and anti-cancer properties, making it a topic of interest for medical and pharmaceutical research. It has also been used in the synthesis of various pharmaceutical compounds and as a precursor in the production of other organic compounds. Additionally, chalcone has been studied for its potential applications in the field of material science, particularly in the development of organic light-emitting diodes and other optoelectronic devices.

InChI:InChI=1/C16H14O3/c1-11-3-5-12(6-4-11)15(17)16(18)13-7-9-14(19-2)10-8-13/h3-10H,1-2H3

Upstream product

• 622-47-9 4-tolylacetic acid 
• 100-66-3 methoxybenzene 
• 1866-39-3 4-methylcinnamic acid 
• 696-62-8 para-iodoanisole 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 5720-07-0 4-methoxyphenylboronic acid 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 
• 104-94-9 4-methoxy-aniline 
• 35675-44-6 4-methylphenylacetyl chloride 
• 57297-25-3 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethanone 
• 637-69-4 4-Methoxystyrene 
• 25856-03-5 1-(4-methoxy-phenyl)-3-p-tolyl-propane-1,3-dione 
• 24785-38-4 1-methoxy-4-[2-(4-methylphenyl)ethynyl]benzene 

Downstream Products

• 345617-51-8 2-(4-methoxyphenyl)-1-(4-methylphenyl)ethanone 
• 57297-25-3 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethanone 
• 1266239-30-8 2-(4-methoxyphenyl)-3-p-tolylquinoxaline 
• 1028432-47-4 5-(4-methoxyphenyl)-5-p-tolylimidazolidine-2,4-dione 
• 1028432-48-5 5-(4-methoxyphenyl)-2-thioxo-5-p-tolylimidazolidin-4-one 

Relevant articles and documents

Visible-Light-Induced Photocatalytic Oxidative Decarboxylation of Cinnamic Acids to 1,2-Diketones

A concerted metallophotoredox catalysis has been realized for the efficient decarboxylative functionalization of α,β-unsaturated carboxylic acids with aryl iodides in the presence of perylene bisimide dye to afford 1,2-diketones.

Two-Step One-Pot Synthesis of Unsymmetrical (Hetero)Aryl 1,2-Diketones by Addition-Oxygenation of Potassium Aryltrifluoroborates to (Hetero)Arylacetonitriles

An efficient one-pot two-step procedure for the synthesis of unsymmetrical (hetero)aryl 1,2-diketones has been developed. The reaction proceeds through a palladium-catalyzed nucleophilic addition of potassium aryltrifluoroborates to aliphatic nitriles followed by a copper-catalyzed aerobic benzylic C–H oxygenation using molecular oxygen as a green oxidant. This represents the first example of the direct synthesis of unsymmetrical diaryl 1,2-diketones from arylacetonitriles. This method utilizes inexpensive, stable, nontoxic, and readily available starting materials, is highly effective in the presence of both electron-rich and electron-poor nitriles and aryltrifluoroborates, and tolerates a wide variety of functional groups. The synthetic utility of this transformation was shown by increasing the scale of the reaction and by carrying out the one-pot protocol for the preparation of quinoxaline and benzimidazole derivatives. A plausible reaction mechanism has also been proposed.

Copper-catalyzed base-accelerated direct oxidation of C-H bond to synthesize benzils, isatins, and quinoxalines with molecular oxygen as terminal oxidant

We describe herein an efficient and general copper (II)-catalyzed base-accelerated oxidation of the C-H bond to synthesize benzils and isatins. With similar oxidation system an efficient one-pot procedure for the synthesis of quinoxaline derivatives was realized. The two protocols feature using molecular oxygen as terminal oxidant, low catalyst loading, wide substrate scope, and high functional-group tolerance.