33429-09-3

Basic information

• Product Name: Methanone, 2-benzothiazolyl(4-methylphenyl)-
• CAS NO: 33429-09-3
• Molecular Formula: C15H11NOS
• Molecular Weight: 253.324
• Mol File: 33429-09-3.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: Methanone, 2-benzothiazolyl(4-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanone, 2-benzothiazolyl(4-methylphenyl)-(33429-09-3)
• EPA Substance Registry System: Methanone, 2-benzothiazolyl(4-methylphenyl)-(33429-09-3)

Safety Data

• Hazardous Substances Data: 33429-09-3(Hazardous Substances Data)

Upstream product

• 32137-73-8 2-(trimethylsilyl)benzothiazole 
• 874-60-2 4-methyl-benzoyl chloride 
• 62-53-3 aniline 
• 615-43-0 2-iodophenylamine 
• 122-00-9 para-methylacetophenone 
• 95-16-9 1,3-Benzothiazole 
• 136-95-8 2-amino-benzthiazole 
• 88-73-3 2-Chloronitrobenzene 
• 7163-50-0 (4-methylphenyl)(oxo)acetic acid 
• 2947-61-7 (4-methylphenyl)acetonitrile 
• 137-07-5 2-amino-benzenethiol 
• 1141-88-4 2-Aminophenyl disulfide 
• 106-42-3 para-xylene 
• 766-97-2 4-n-methylphenylacetylene 

Downstream Products

• 62487-38-1 bis(1,3-benzothiazol-2-yl)(4-methylphenyl)methanol 

Relevant articles and documents

One-pot synthesis of 2-acylbenzothiazoles from 2-aminobenzenethiols and arylacetonitriles via cyclization and sequential oxidation

An efficient one-pot method to access 2-acylbenzothiazoles via AlCl3-mediated cyclization reaction and I2-promoted sequential oxidation reaction of 2-aminobenzenethiols with arylacetonitriles was developed. This reaction proceeds smoothly with a wide range of arylacetonitriles containing different functional groups to give the corresponding products in moderate to good yields under mild conditions. Moreover, this reaction was conveniently conducted on a gram scale, and the yield is still up to 68%.

Visible-light-promoted photocatalyst-free alkylation and acylation of benzothiazoles

Herein we report a protocol for the visible-light-mediated alkylation/acylation reaction of benzothiazoles. Alkyl/acyl substituted Hantzsch esters are easily prepared and rationally used as radical precursors. In the presence of BF3·Et2O and Na2S2O8, various benzothiazole derivatives were readily obtained in good yields. Our user-friendly protocol can proceed by simple irradiation with blue LEDs (λ = 465 nm) and without the assistance of external photocatalysts. The reaction is also characterized by mild conditions and scalability, thus offering an alternative and efficient tool for the synthesis of 2-functionalized benzothiazoles.

C2-arylacylation of 2H-benzothiazoles with methyl arenes via Selectfluor oxidation

An efficient Selectfluor-oxidative protocol was developed for the direct C2-arylacylation of 2H-benzothiazoles via the radical reaction of 2H-benzothiazoles with methyl arenes. Selectfluor can effectively promote the oxidative cross-coupling without an ex