33439-27-9Relevant articles and documents
Synthesis of novel 1,3-thiazin-4-ones by acetylene diester cyclization and their anticancer activities
Anand, Selvam Athavan Alias,Loganathan, Chandrasekaran,Thomas, Nisha Susan,Saravanan, Kuppusamy,Alphonsa, Antony Therasa,Kabilan, Senthamaraikannan
, p. 1396 - 1401 (2016)
A novel series of 1,3-thiazin-4-one derivatives containing a piperidyl ring (7–16) were designed and synthesized efficiently by thioamide and acetylene diester cyclization reaction via aminolysis of the ester group and the elimination of an alcohol molecu
Metal-free Photochemical Atom Transfer Radical Addition (ATRA) of BrCCl3 to Alkenes
Nikitas, Nikolaos F.,Voutyritsa, Errika,Gkizis, Petros L.,Kokotos, Christoforos G.
supporting information, p. 96 - 101 (2021/01/04)
A simple, photochemical, and metal-free protocol for the atom transfer radical addition (ATRA) of bromotrichloromethane onto various alkenes is described. Among a range of organic molecules, phenylglyoxylic acid proved to be the most suitable photoinitiator to promote a sustainable process for the addition of bromotrichloromethane to olefins. This photochemical atom transfer radical protocol can be expanded into a wide substrate scope of aliphatic olefins bearing various functional groups, leading to the corresponding products in good to excellent yields.
Synthesis of α-Quaternary Bicyclo[1.1.1]pentanes through Synergistic Organophotoredox and Hydrogen Atom Transfer Catalysis
Anderson, Edward A.,Frank, Nils,Mousseau, James J.,Nugent, Jeremy,Sterling, Alistair J.
supporting information, p. 8628 - 8633 (2021/11/17)
Bicyclo[1.1.1]pentanes (BCPs) are important in drug design as sp3-rich bioisosteres of arenes and tert-butyl groups; however, the preparation of BCPs with adjacent quaternary carbons is barely known. We report a facile synthesis of α-quaternary BCPs using organophotoredox and hydrogen atom transfer catalysis in which α-keto radicals, generated through oxidation of β-ketocarbonyls, undergo efficient addition to [1.1.1]propellane. The BCP products can be transformed into a variety of useful derivatives, including enantioenriched BCPs featuring α-quaternary stereocenters.