334711-70-5Relevant articles and documents
Heterocyclization of 2-chloro-1-cyano-1-diethoxyphosphoryl-2- trifluoromethylethylene and 2-chloro-2-chlorodifluoromethyl-1-cyano-1- diethoxyphosphorylethylene
Shidlovskii,Peregudov,Averkiev,Antipin,Chkanikov
, p. 2060 - 2070 (2004)
The reactions of 2-chloro-1-cyano-1-diethoxyphosphoryl-2- trifluoromethylethylene (2a) and 2-chloro-2-chlorodifluoromethyl-1-cyano-1- diethoxyphosphorylethylene (2b) with arylamines, arylhydrazines, amidines, 2-aminopyridines, and 5-aminopyrazoles were studied. Alkenes 2a, b can serve as precursors of aminopyrazoles, pyrimidines, pyrido[1,2-a]pyrimidines, and pyrazolo[1,5-a]pyrimidines modified with the fluoroalkyl and diethoxyphosphoryl groups. Intermediates of some heterocyclization reactions were detected by NMR spectroscopy. The structures of the compounds were confirmed by X ray diffraction analysis.
Reactions with N-chlorosuccinimide of various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position
Ikemoto, Tomomi,Wakimasu, Mitsuhiro
, p. 99 - 108 (2007/10/03)
Chlorination reactions using N-chlorosuccinimide (NCS) was investigated for various 5-methylimidazo[1,2-a]pyridine derivatives with an electron-withdrawing group substituted at the 3-position. These reactions showed different results, and by examining these, we proposed a reaction mechanism via the appropriate 3-halogenoimidazo[1,2-a]pyridium compounds as the reaction intermediates.
