334758-22-4

Basic information

• Product Name: Benzoic acid, 2-(carboxymethoxy)-5-chloro-
• Synonyms: 2-Carboxymethoxy-5-chlor-benzoesaeure
• CAS NO: 334758-22-4
• Molecular Formula: C9H7ClO5
• Molecular Weight: 230.605
• Mol File: 334758-22-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 434.9±30.0 °C(Predicted)
• Density: 1.547±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Benzoic acid, 2-(carboxymethoxy)-5-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-(carboxymethoxy)-5-chloro-(334758-22-4)
• EPA Substance Registry System: Benzoic acid, 2-(carboxymethoxy)-5-chloro-(334758-22-4)

Safety Data

• Hazardous Substances Data: 334758-22-4(Hazardous Substances Data)

Upstream product

• 172088-80-1 methyl 5-chloro-2-(2-methoxy-2-oxoethoxy)benzoate 
• 57202-99-0 (2-carbethoxy-4-chlorophenoxy)-acetic acid ethyl ester 
• 670-62-2 methyl 5-chloro-2-(2-ethoxy-2-oxoethoxy)benzoate 
• 635-53-0 (2-carboxyphenoxy)acetic acid 

Downstream Products

• 3261-05-0 5-chlorobenzofuran-3(2H)-one 
• 172088-80-1 methyl 5-chloro-2-(2-methoxy-2-oxoethoxy)benzoate 

Relevant articles and documents

Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity

Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT1A receptor affinities. Their design, synthesis and structure-activity relationships are described.

Synthesis, antibacterial activity, and quantitative structure-activity relationships of new (Z)-2-(nitroimidazolylmethylene)-3(2 H)-benzofuranone derivatives

A new series of (Z)-2-(1-methyl-5-nitroimidazole-2-ylmethylene)-3(2 H)-benzofuranones (11a-p) and (Z)-2-(1-methyl-4-nitroimidazole-5-ylmethylene)-3(2 H)-benzofuranones (12a-m) were synthesized and assayed for their antibacterial activity against Gram-positive and Gram-negative bacteria. Most of the 5-nitroimidazole analogues (11a-p) showed a remarkable inhibition of a wide spectrum of Gram-positive bacteria (Staphylococcus aureus, Streptococcus epidermidis, MRSA, and Bacillus subtilis) and Gram-negative Klebsiella pneumoniae, whereas 4-nitroimidazole analogues (12a-m) were not effective against selected bacteria. The quantitative structure-activity relationship investigations were applied to find out the correlation between the experimentally evaluated activities with various parameters of the compounds studied. The QSAR models built in this work had reasonable predictive power and could be explained by the observed trends in activities.

BENZOFURANYL-AND BENZOTHIENYL-PIPERAZINYL QUINOLINES AND METHODS OF THEIR USE

Benzofuranyl-and benzothienyl-piperzinyl quinoline derivatives and compositions containing such compounds are disclosed. Methods of using benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives and compositions containing such composition in the treatment and/or prevention of serotonin-related disorders, such as depression and anxiety, are also disclosed. In addition, processes for the preparation of benzofuranyl- and benzothienyl-piperzinyl quinoline derivatives are disclosed.