3351-43-7Relevant articles and documents
Synthesis and biological evaluation of modified 2-deoxystreptamine dimers
Coste, Gerald,Horlacher, Tim,Molina, Lidia,Moreno-Vargas, Antonio J.,Carmona, Ana T.,Robina, Inmaculada,Seeberger, Peter H.,Gerber-Lemaire, Sandrine
experimental part, p. 1759 - 1770 (2011/07/30)
Aminoglycosides are powerful antibiotics, but the emergence of resistant bacterial strains has prompted the search for analogues with better pharmacological profiles. The synthesis of 2-deoxystreptamine (2-DOS) dimers linked by polyamines and analogues based on furylcarbopeptoid skeletons is described. Potent and selective ligands for bacterial 16S rRNA were identified using microarray techniques by determining the affinity of these derivatives toward bacterial and human ribosomal RNAs. Georg Thieme Verlag Stuttgart - New York.
SiO2-supported CeCl3·7H2O-NaI Lewis acid promoter: Investigation into the Garcia Gonzalez reaction in solvent-free conditions
Bartoli, Giuseppe,Fernandez-Bolanos, Jose G.,Di Antonio, Giustino,Foglia, Gioia,Giuli, Sandra,Gunnella, Roberto,Mancinelli, Michele,Marcantoni, Enrico,Paoletti, Melissa
, p. 6029 - 6036 (2008/02/10)
(Chemical Equation Presented) The Knoevenagel condensation of aldose sugars with β-dicarbonyl compounds produces furan derivatives having polyhydroxyalkylated alkyl side chains; this reaction is known as the Garcia Gonzalez reaction. Despite the fact that