33577-83-2

Basic information

• Product Name: Benzamide, 4-(acetyloxy)-N-phenyl-
• CAS NO: 33577-83-2
• Molecular Formula: C15H13NO3
• Molecular Weight: 255.273
• Mol File: 33577-83-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzamide, 4-(acetyloxy)-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzamide, 4-(acetyloxy)-N-phenyl-(33577-83-2)
• EPA Substance Registry System: Benzamide, 4-(acetyloxy)-N-phenyl-(33577-83-2)

Safety Data

• Hazardous Substances Data: 33577-83-2(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 27914-73-4 4-acetoxybenzoyl chloride 

Downstream Products

• 102827-03-2 (4-(dimethylamino)phenyl)(4-hydroxyphenyl)methanone 
• 14121-97-2 4-hydroxybenzanilide 

Relevant articles and documents

Aryl alkyl ether compound as well as derivative, preparation method, pharmaceutical composition and application thereof

The invention discloses an aryl alkyl ether compound as well as a derivative, a preparation method, a pharmaceutical composition and application thereof. The structure of the aryl alkyl ether compound is shown as a formula (I). The aryl alkyl ether compound derivative relates to a stereoisomer, a tautomer, a metabolite, a metabolic precursor, a prodrug, a solvate, a salt of the solvate, a crystal, a pharmaceutically acceptable salt or a mixture of the stereoisomer, the tautomer, the metabolite, the metabolic precursor, the prodrug and the solvate of the aryl alkyl ether compound. The aryl alkyl ether compound and the derivative thereof have a remarkable inhibition effect on indoleamine 2, 3-dioxygenase 1, and can be used for preparing a medicine for treating indoleamine 2, 3-dioxygenase 1 mediated immunosuppression related diseases, and the prepared medicine can exert the medicine effect at the molecular level and is wide in application.

QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY

Compounds of formula (IA) or (IB), are inhibitors of aurora kinase activity: Formula (IA), (IB) wherein -L1Y1-[CH2]z- is a linker radical wherein Y1, L1 and z are as defined in the claims; R6 is C1-C4alkoxy, hydrogen or halo; W represents a bond, -CH2-, -O-, -S-, -S(=O)2-, or -NR5- where R5 is hydrogen or C1-C4 alkyl; Q is =N-, =CH- or =C(X1)- wherein X1 is cyano, cyclopropyl or halo; linker radicals L2 are as defined in the claims; R is a radical of formula (X) or (Y): wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroaryl(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and D is a monocyclic heterocyclic ring of 5 or 6 ring atoms.