33605-76-4

Basic information

• Product Name: FOR-ASP-PHE-OME
• Synonyms: FORMYL ASPARTAME;FOR-ASP-PHE-OME;1-methyl N-(N-formyl-L-alpha-aspartyl)-3-phenyl-L-alaninate;CHO-L-Asp-L-Phe-OMe;For-L-Asp-L-Phe-OMe;N-Formyl-L-αAsp-L-Phe-OMe;N-Formyl-alpha-aspartylphenylalanine methyl ester;N-Formyl-alpha-L-aspartyl-L-phenylalanine methyl ester
• CAS NO: 33605-76-4
• Molecular Formula: C₁₅H₁₈N₂O₆
• Molecular Weight: 322.31
• EINECS: 251-590-3
• Mol File: 33605-76-4.mol
• Article Data: 6

Chemical Properties

• Melting Point: 138-141℃
• Boiling Point: 643.513 °C at 760 mmHg
• Flash Point: 342.985 °C
• Appearance: /
• Density: 1.295
• CAS DataBase Reference: FOR-ASP-PHE-OME(CAS DataBase Reference)
• NIST Chemistry Reference: FOR-ASP-PHE-OME(33605-76-4)
• EPA Substance Registry System: FOR-ASP-PHE-OME(33605-76-4)

Safety Data

• Hazardous Substances Data: 33605-76-4(Hazardous Substances Data)

Usage

General Description

FOR-ASP-PHE-OME is a chemical compound consisting of the amino acids phenylalanine, aspartic acid, and a formyl group. It is commonly used as a building block in peptide synthesis and pharmaceutical research. The presence of the formyl group allows for selective modification of the peptide, making it a valuable tool in chemical biology and drug development. FOR-ASP-PHE-OME has also been studied for its potential anti-inflammatory and analgesic properties, making it a promising candidate for the development of new medications. Its unique chemical structure and diverse pharmacological properties make it a versatile and important compound in the field of medicinal chemistry.

Upstream product

• 116147-62-7 n-formyl-l-aspartic anhydride 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 19427-28-2 N-formyl-L-aspartic acid 
• 100101-47-1 (Z)-N-(N-formyl-α-L-aspartyl)-Δ-phenylalanine methyl ester 
• 33605-73-1 N-(2,5-Dioxo-tetrahydro-furan-3-yl)-formamide 
• 2577-90-4 L-phenylalanine methyl ester 

Downstream Products

• 22839-47-0 L-Asp-L-Phe-OMe 
• 5910-52-1 α-L-aspartyl-L-phenylalanine methyl ester hydrochloride 

Relevant articles and documents

THE TRANSFORMYLATION REACTION - TRANSFER OF AN N-FORMYL RESIDUE IN AMINO ACID AND PEPTIDE DERIVATIVES TO NUCLEOPHILIC GROUPS - AS A SIDE REACTION OF PEPTIDE SYNTHESIS

In the course of a study of the enzymatic synthesis of peptides from N-formylamino acids, the transfer of a formyl group to nucleophilic acceptors present in the aqueous-organic reaction medium - amino acid esters, peptides, and aromatic amines - has been detected, and this to the greater degree the higher the nucleophilicity of the acceptor.The transfer of a formyl group from a number of formylamino acids and formylpeptides to phenylalanine methyl ester has been studied.A fall in the yield of the transformylation reaction on passing from formyl derivatives with a free carboxy group to formyl peptides or esterified formylamino acids has been found.No transfer of an acetyl group was observed under these conditions.On the use of formyl derivatives in peptide synthesis the possibility of the occurrence of the transformylation reaction and the resulting appearance of by-products must be taken into account.Key words: peptide; enzymatic synthesis; transformylation.

Untersuchungen zum Einfluss verschiedener Reaktionsparameter auf die Synthese von N-Formylaspartam

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Synthesis of Aspartame via Asymmetric Hydrogenation of N-Protected (Z)-N-α-L-Aspartyl-Δ-phenylalanine Methyl Ester

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