33617-40-2

Basic information

• Product Name: 1,3-Benzenediol, 5-(bromomethyl)-
• CAS NO: 33617-40-2
• Molecular Formula: C7H7BrO2
• Molecular Weight: 203.035
• Mol File: 33617-40-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1,3-Benzenediol, 5-(bromomethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenediol, 5-(bromomethyl)-(33617-40-2)
• EPA Substance Registry System: 1,3-Benzenediol, 5-(bromomethyl)-(33617-40-2)

Safety Data

• Hazardous Substances Data: 33617-40-2(Hazardous Substances Data)

Usage

Molecular structure

A benzene ring with two hydroxyl (-OH) groups at the 1 and 3 positions, and a bromomethyl (-CH2Br) substituent at the 5 position.

Functional groups

Hydroxyl, bromomethyl

Appearance

Unknown, but likely a solid or liquid depending on the conditions

Physical properties

Unknown, but likely has a high melting or boiling point due to the presence of the hydroxyl groups, which can form hydrogen bonds

Solubility

Unknown, but likely soluble in organic solvents such as ethanol or acetone due to the presence of the benzene ring

Reactivity

Reacts with nucleophiles to form various biologically active compounds and functionalized benzenediols

Uses

Widely used in the synthesis of pharmaceuticals, agrochemicals, and dyes; serves as a valuable building block in organic chemistry; used as a reagent in the preparation of functionalized benzenediols; used in the synthesis of novel scaffolds for drug development and as a starting material for the synthesis of specialty chemicals.

Safety

Unknown, but likely toxic and harmful if ingested, inhaled, or absorbed through the skin; should be handled with care and proper safety measures should be taken.

Upstream product

• 29654-55-5 5-(hydroxymethyl)benzene-1,3-diol 
• 24131-31-5 3,5-dibenzyloxybenzyl alcohol 
• 877-88-3 3,5-dimethoxybenzyl bromide 

Downstream Products

• 817592-71-5 {[3,5-bis(methoxymethoxy)phenyl]methyl}phosphonic acid diethyl ester 
• 158139-69-6 5-(bromomethyl)-1,3-bis(tert-butyldimethylsilyloxy)-benzene 
• 33617-50-4 3.5-Dihydroxy-benzylphosphonsaeurediaethylester 
• 29680-77-1 (3,5-dihydroxybenzyl)triphenylphosphonium bromide 
• 1018449-53-0 3',4'-bis(tert-butyldimethylsiloxy)-3,5-dihydroxystilbene 
• 29680-76-0 3,5-diacetoxybenzyl-(triphenyl)phosphonium bromide 
• 10083-24-6 trans-piceatannol 
• 908118-10-5 5-(azidomethyl)benzene-1,3-diol 

Relevant articles and documents

Total Synthesis of Gramistilbenoids A, B, and C

Stilbenes are biologically active metabolites of plants that have the potential to attenuate a broad range of human diseases. Gramistilbenoids are a class of natural products with a stilbene skeleton, isolated from the bamboo orchid (Arundina graminifolia), and with significant cytotoxicity against cancer cell lines (NB4, A549, SHSY5Y, PC3, and MCF7). These are the first identified naturally occurring diphenylethylenes to possess a hydroxyethyl unit. However, some of these compounds are not abundant in nature, and thus, their synthesis is advantageous. This paper reports the first synthesis of gramistilbenoids A (1), B (2), and C (3), with overall yields of 10, 2, and 8% respectively. These natural products were synthesized using key reactions, such as Horner-Wadsworth-Emmons olefination, Stille coupling, and hydroboration-oxidation.

Efficient synthesis of small-sized phosphonated dendrons: Potential organic coatings of iron oxide nanoparticles

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