33630-96-5

Basic information

• Product Name: 5-AMINO-1-METHYLPYRIDIN-2(1H)-ONE
• Synonyms: 5-AMINO-1-METHYLPYRIDIN-2(1H)-ONE;5-Amino-1-methylpyridin-2...;5-AMino-1-Methyl-2(1H)-pyridinone;5-AMino-1-Methylpyridin-2(1H)-one oxalate;5-AMino-1-Methylpyridin-2(1H)-one heMioxalate;bis(5-amino-1-methyl-1,2-dihydropyridin-2-one);5-Amino-1-methyl-1H-pyridin-2-one;5-Amino-N-methyl-2-pyridone
• CAS NO: 33630-96-5
• Molecular Formula: C₆H₈N₂O
• Molecular Weight: 124.14
• Mol File: 33630-96-5.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-AMINO-1-METHYLPYRIDIN-2(1H)-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-AMINO-1-METHYLPYRIDIN-2(1H)-ONE(33630-96-5)
• EPA Substance Registry System: 5-AMINO-1-METHYLPYRIDIN-2(1H)-ONE(33630-96-5)

Safety Data

• Hazardous Substances Data: 33630-96-5(Hazardous Substances Data)

Usage

General Description

5-Amino-1-methylpyridin-2(1H)-one is a chemical compound belonging to the class of organic compounds known as pyridinones. Its molecular formula is C6H8N2O. This chemical is known for its light yellow physical appearance and it exists as a solid substance at room temperature. Characteristically, it has a moderately high boiling point. Its potential applications could be as intermediates for the synthesis of various compounds in the chemical industry. However, there is not much information available about its usage and safety handling. As with all chemicals, proper safety measures should be taken when handling 5-Amino-1-methylpyridin-2(1H)-one.

Upstream product

• 32896-90-5 1-methyl-5-nitro-2(1H)-pyridone 
• 168007-90-7 tert-butyl (1-methyl-6-oxo-1,6-dihydropyridin-3-yl)carbamate 
• 5418-51-9 5-nitro-2-hydroxypyridine 
• 5418-51-9 5-nitro-2-pyridone 

Downstream Products

• 1370652-56-4 {5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-6-aminopyridazin-3-yl}-N-(1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)carboxamide 
• 1179143-37-3 2-fluoro-N-(1-methyl-6-oxo-1,6-dihydropyridin-3-yl)benzenesulfonamide 
• 1620847-53-1 4-(tert-butyl)-N-(1-methyl-2-oxo-1,2-dihydropyridin-4-yl)-2-((6-(trifluoromethyl)pyridin-3-yl)oxy)benzamide 

Relevant articles and documents

Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d[pyrimidine derivatives as potent Mnk inhibitors: Synthesis, structure-activity relationship analysis and biological evaluation

Phosphorylation of the eukaryotic initiation factor 4E (eIF4E) by mitogen-activated protein kinase (MAPK)-interacting kinases (Mnks) is essential for oncogenesis but unnecessary for normal development. Thus, pharmacological inhibition of Mnks may offer an effective and non-toxic anti-cancer therapeutic strategy. Herein, we report the discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors. Docking study of 7a in Mnk2 suggests that the compound is stabilised in the ATP binding site through multiple hydrogen bonds and hydrophobic interaction. Cellular mechanistic studies on MV-4-11 cells with leads 7a, 8e and 8f reveal that they are able to down-regulate the phosphorylated eIF4E, Mcl-1 and cyclin D1, and induce apoptosis.

IMIDAZOPYRROLIDINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

SUBSTITUTED PYRIDAZINE CARBOXAMIDE COMPOUNDS AS KINASE INHIBITOR COMPOUNDS

Pyridazine derivatives have unexpected drug properties as inhibitors of protein kinases and are useful in treating disorders related to abnormal protein kinase activities such as cancer.