33671-46-4 Usage
Description
CLOTIAZEPAM is a thienodiazepine derivative that exhibits anxiolytic, skeletal muscle relaxant, anticonvulsant, and sedative properties. It also contributes to a significant increase in stage 2 NREM sleep. CLOTIAZEPAM binds to the benzodiazepine site of the GABAA receptor, acting as a full agonist and enhancing the GABA inhibitory effect at the GABAA receptor. It is classified as a controlled substance and has off-white solid chemical properties.
Uses
Used in Pharmaceutical Industry:
CLOTIAZEPAM is used as an anxiolytic agent for treating anxiety disorders and reducing anxiety symptoms. Its anxiolytic properties help alleviate stress and promote relaxation in patients.
CLOTIAZEPAM is used as a skeletal muscle relaxant for managing muscle spasms and pain. It helps in reducing muscle tension and providing relief from discomfort associated with muscle-related conditions.
CLOTIAZEPAM is used as an anticonvulsant for controlling seizures and preventing their recurrence. Its anticonvulsant properties help stabilize the electrical activity in the brain, reducing the frequency and severity of seizures.
CLOTIAZEPAM is used as a sedative for inducing sleep and promoting relaxation in patients with insomnia or other sleep disorders. It enhances the GABA inhibitory effect at the GABAA receptor, leading to a calming effect and improved sleep quality.
CLOTIAZEPAM is used as a treatment for increasing stage 2 NREM sleep, which is essential for overall sleep quality and well-being. By increasing the duration of this sleep stage, CLOTIAZEPAM contributes to better rest and recovery for the individual.
Originator
Rize,Yoshitomi,Japan,1979
Manufacturing Process
To a solution of 10 g of 2-N-methylaminoacetamido-3-o-chlorobenzoyl-5-ethylthiophene in 50 ml of pyridine are added 20 ml of benzene and 1.9 g of
acetic acid. The resulting mixture is refluxed with stirring for 10 hours in a
flask provided with a water-removing adaptor. The reaction mixture is
concentrated, and the residue is extracted with chloroform. The chloroform
layer is washed with water and then with a sodium hydrogen carbonate
solution, then dried over magnesium sulfate. The chloroform is distilled off
under reduced pressure, and toluene is added to the residue. Thus is
precipitated white crystalline-5-o-chlorophenyl-7-ethyl-1-methyl-1,2-dihydro-
3H-thieno-[2,3-e][1,4]diazepin-2-one, MP 105°C to 106°C.
Therapeutic Function
Tranquilizer
Check Digit Verification of cas no
The CAS Registry Mumber 33671-46-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,6,7 and 1 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 33671-46:
(7*3)+(6*3)+(5*6)+(4*7)+(3*1)+(2*4)+(1*6)=114
114 % 10 = 4
So 33671-46-4 is a valid CAS Registry Number.
InChI:InChI=1/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3
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