33757-42-5

Basic information

• Product Name: N-(quinolin-8-yl)acetamide
• Synonyms: acetamide, N-8-quinolinyl-; N-(8-Quinolinyl)acetamide
• CAS NO: 33757-42-5
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.2099
• Mol File: 33757-42-5.mol
• Article Data: 32

Chemical Properties

• Boiling Point: 430.9°C at 760 mmHg
• Flash Point: 214.4°C
• Density: 1.242g/cm³
• Vapor Pressure: 1.25E-07mmHg at 25°C
• Refractive Index: 1.677
• CAS DataBase Reference: N-(quinolin-8-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(quinolin-8-yl)acetamide(33757-42-5)
• EPA Substance Registry System: N-(quinolin-8-yl)acetamide(33757-42-5)

Safety Data

• Hazardous Substances Data: 33757-42-5(Hazardous Substances Data)

Usage

General Description

N-(quinolin-8-yl)acetamide is a chemical compound with the molecular formula C12H10N2O. It is an amide derivative of quinoline and acetamide, and it is commonly used in organic synthesis and pharmaceutical research. N-(quinolin-8-yl)acetamide has potential applications in medicinal chemistry, particularly in the development of new drugs for various diseases such as cancer and neurodegenerative disorders. N-(quinolin-8-yl)acetamide exhibits diverse biological activities and has been investigated for its antitumor, antifungal, and antibacterial properties. Its structure and properties make it an important building block in the synthesis of novel compounds with potential therapeutic benefits.

Upstream product

• 578-66-5 8-amino quinoline 
• 108-24-7 acetic anhydride 
• 607-35-2 8-nitroquinoline 
• 14040-11-0 tungsten hexacarbonyl 
• 616-38-6 carbonic acid dimethyl ester 
• 507-09-5 tiolacetic acid 
• 127-19-5 N,N-dimethyl acetamide 
• 563-63-3 silver(I) acetate 
• 33757-46-9 8-(N-propionylamino)quinoline 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 64-19-7 acetic acid 
• 190137-71-4 3-phenylquinolin-8-amine 
• 75-36-5 acetyl chloride 

Downstream Products

• 99840-76-3 N-(1,2,3,4-tetrahydroquinolin-8-yl)acetamide 
• 477531-98-9 N-(5,6,7,8-tetrahydroquinolin-8-yl)acetamide 
• 298181-98-3 1-Methyl-8-amino-1,2,3,4-tetrahydroquinoline 
• 85656-73-1 2,4,6-Trimethyl-benzenesulfonate8-acetylamino-1-amino-quinolinium; 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 578-66-5 8-amino quinoline 

Relevant articles and documents

Nickel-Catalyzed Reaction of Benzamides with Bicylic Alkenes: Cleavage of C-H and C-N Bonds

The nickel-catalyzed reaction of aromatic amides that contain an 8-aminoquinoline as a directing group with bicyclic alkenes, such as norbornene and 1,4-dihydro-1,4-epoxynaphthalene, results in the cleavage of both the C-H bond at the ortho-position of th

C-5 selective chlorination of 8-aminoquinoline amides using dichloromethane

An oxidant-free electrochemical regioselective chlorination of 8-aminoquinoline amides at ambient temperature in batch and continuous-flow was achieved. Inert DCM was used as the chlorinating reagent. Owing to the continuous-flow setup, the reaction scale

3,6-Di(pyridin-2-yl)-1,2,4,5-tetrazine (pytz) catalysed metal-free amide bond formation from thioacids and amines at room temperature

A 3,6-di(pyridin-2-yl)-1,2,4,5-tetrazine (pytz) catalysed efficient, mild and metal-free method has been developed for direct amide bond synthesis from simple thioacids and amines as starting materials. This methodology is useful for aromatic, aliphatic, and heteroaromatic thioacids as well as primary, secondary, heterocyclic, and even functionalized amines. A wide substrates scope, operationally mild conditions, and acylation of amines without affecting other functional groups such as alcohols, esters, carbodithioates, among others make this strategy very attractive and practical.