33762-81-1

Basic information

• Product Name: (1S,4aα)-Decahydro-2β,5,5,8aβ-tetramethyl-1β-naphthalenemethanol
• Synonyms: (1S,4aα)-Decahydro-2β,5,5,8aβ-tetramethyl-1β-naphthalenemethanol;8β-Drimanol
• CAS NO: 33762-81-1
• Molecular Formula: C₁₅H₂₈O
• Molecular Weight: 224.38222
• Mol File: 33762-81-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1S,4aα)-Decahydro-2β,5,5,8aβ-tetramethyl-1β-naphthalenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4aα)-Decahydro-2β,5,5,8aβ-tetramethyl-1β-naphthalenemethanol(33762-81-1)
• EPA Substance Registry System: (1S,4aα)-Decahydro-2β,5,5,8aβ-tetramethyl-1β-naphthalenemethanol(33762-81-1)

Safety Data

• Hazardous Substances Data: 33762-81-1(Hazardous Substances Data)

Upstream product

• 54632-04-1 albicanol 
• 856683-41-5 ((2S,4aS,5S,8aR)-decahydro-2-hydroxy-1,1,4a-trimethyl-6-methylenenaphthalen-5-yl)methyl acetate 
• 93861-36-0 essigsaeure-<(E,E,10S)-10,11-epoxy-3,7,11-trimethyl-2,6-dodecadien-1-yl>ester 
• 130790-62-4 (R,2E,6E)-10,11-dihydroxy-3,7,11-trimethyldodeca-2,6-dienyl acetate 
• 4128-17-0 (2E,6E)-farnesyl acetate 
• 34175-53-6 (S,2E,6E)-9-(3,3-dimethyloxiran-2-yl)-3,7-dimethylnona-2,6-dien-1-ol 
• 106-28-5 Farnesol 
• 468-68-8 (-)-drimenol 
• 52617-99-9 (+)-drimane-8,11-diol 
• 20404-57-3 12,13,14,15,16-pentanorlabdan-11-oic acid 
• 83679-71-4 [(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl acetate 
• 74636-06-9 uvidin A 
• 74635-87-3 6-oxo-7-drimen-11-ol 
• 34437-62-2 drimendiol 

Downstream Products

• 51020-10-1 isonordrimenone 
• 5951-58-6 8α(H)-drimane 

Relevant articles and documents

Enantioselective Total Synthesis of (–)-Siphonodictyal B and (+)-8-epi-Siphonodictyal B with Phosphatidylinositol 3-Kinase α (PI3Kα) Inhibitory Activity

The biologically interesting marine meroterpenoids (–)-siphonodictyal B and (+)-8-epi-siphonodictyal B were efficiently synthesized in 29–40 % overall yield in a longest linear sequence of 11 steps, starting from commercially available (+)-sclareolide. The synthesis involved the following crucial steps: (i) stereodivergent hydrogenation of a homoallylic decalin alcohol to install the requisite C8 stereogenic centre present in the decalin fragments; (ii) coupling of the decalin fragments with an aromatic moiety to assemble the desired carbon skeletons; and (iii) deprotection from multiple O-protective groups on the aromatic ring to complete the project synthesis. Both (–)-siphonodictyal B and (+)-8-epi-siphonodictyal B showed PI3Kα inhibitory activity, with potencies comparable to that of liphagal, a naturally occurring PI3Kα inhibitor. New structure–activity relationships for this class of marine meroterpenoids were also revealed.

Synthesis of the Sesquiterpenes Albicanol, Drimanol, and Drimanic Acid, and the Marine Sesquiterpene Hydroquinone Deoxyspongiaquinol

A TiIII-mediated radical cyclization cascade has been used for the synthesis of the sesquiterpenes (+)-albicanol, (+)-drimanol, and (+)-drimanic acid. Starting from all-trans-farnesol, (+)-albicanol could be prepared in seven steps in an overal

Comparative study on the larvicidal activity of drimane sesquiterpenes and nordrimane compounds against drosophila melanogaster til-til

Natural compounds from Drimys winteri Forst and derivatives exhibited larvicidal effects against Drosophila melanogaster til-til. The most active compound was isodrimenin (4). The highest lethal concentration to the larvae of D. melanogaster was 4.5 ± 0.8 mg/L. At very low concentrations drimenol (1), confertifolin (3), and drimanol (5) displayed antifeedant and larvae growth regulatory activity. The antifeedant results of nordrimanic and drimanic compounds were better in first instar larvae. The EC50 value of polygodial (2) was 60.0 ± 4.2 mg/L; of diol 15 45.0 ± 2.8 mg/L, and of diol 17 36.9 ± 3.7 mg/L, while the new nordrimane compound 12 presented a value of 83.2 ± 3.5 mg/L.