33767-87-2 Usage
Description
(5alpha,17beta)-3-oxoestran-17-yl acetate, a synthetic estrogen compound, is derived from estradiol, the primary female sex hormone. It functions as an agonist for the estrogen receptor, binding to and activating the receptor, which results in various physiological effects in target tissues. (5alpha,17beta)-3-oxoestran-17-yl acetate is significant in scientific research for understanding estrogen action and serves as a precursor for synthesizing other estrogenic compounds.
Uses
Used in Scientific Research:
(5alpha,17beta)-3-oxoestran-17-yl acetate is used as a research tool for studying the mechanisms of estrogen action in the female reproductive system and secondary sexual characteristics. It aids in comprehending the interactions between estrogen receptors and their target tissues.
Used in Pharmaceutical Industry:
(5alpha,17beta)-3-oxoestran-17-yl acetate is used as a precursor in the synthesis of other estrogenic compounds, which can be utilized for the development of medications targeting hormone-related conditions and therapies.
Used in Hormone Replacement Therapy:
(5alpha,17beta)-3-oxoestran-17-yl acetate may be used as a component in hormone replacement therapy, particularly for conditions where estrogen levels need to be supplemented, such as menopause or specific gynecological disorders.
Used in Fertility Treatments:
(5alpha,17beta)-3-oxoestran-17-yl acetate may also be employed in fertility treatments, where understanding and modulating estrogen levels are crucial for successful conception and pregnancy maintenance.
Check Digit Verification of cas no
The CAS Registry Mumber 33767-87-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,7,6 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 33767-87:
(7*3)+(6*3)+(5*7)+(4*6)+(3*7)+(2*8)+(1*7)=142
142 % 10 = 2
So 33767-87-2 is a valid CAS Registry Number.
33767-87-2Relevant articles and documents
Synthesis of C-6 fluoroandrogens: Evaluation of ligands for tumor receptor imaging
Choe, Yearn Seong,Katzenellenbogen, John A.
, p. 414 - 422 (2007/10/02)
Seven androgens, substituted with fluorine at C-6, were prepared as potential imaging agents for androgen receptor-positive prostate tumors and were evaluated in vitro in terms of their lipophilicity and their relative binding affinities (RBA, relative to R1881 = 100) for the androgen receptor and for sex steroid binding protein.Introduction of a fluorine atom into the C-6 position of an androgen generally decreases binding affinity to the androgen receptor, except in the two cases: 6α-fluoro-19-nor-testosterone RBA = 41.6 versus 30.6 for the unsubstituted steroid) and 6α-fluorotestosterone (RBA = 8.9 versus 6.6).Receptor binding of the C-6 fluoro-androgens is also stereospecific, showing higher binding affinities for the α-epimers compared to the corresponding β-epimers (4:1 - 15:1).Binding affinity to sex steroid binding protein is the lowest with 19-nor-testosterone, which is also the least lipophilic androgen studied.Based on the binding properties of compounds in this series, 6α-fluoro-19-nor-testosterone appears to have the most promise as a tumor imaging agent. - Keywords: C-6-fluoroandrogens; fluorine substitution; relative binding affinity; 6α- and 6β-epimers; log Po/w; prostate tumors
Highly Stereoselective Hydrogenation of 3-Oxo-4-ene and -1,4-diene Steroids to 5β Compounds with Palladium Catalyst
Tsuji, Natsuko,Suzuki, Jun,Shiota, Michio,Takahashi, Izumi,Nishimura, Shigeo
, p. 2729 - 2731 (2007/10/02)
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