3377-71-7Relevant articles and documents
An efficient method for the N-debenzylation of aromatic heterocycles
Rao, T. Srinivasa,Pandey, Pramod S.
, p. 3121 - 3127 (2004)
The N-debenzylation of aromatic heterocycles such as substituted pyrroles and indoles, having functional groups like ester, amide, halo, and nitrile, by using sodium in liquid ammonia in the presence of t-BuOH at -78°C cleanly affords N-debenzylated aromatic heterocycles in good yields.
Regioselective 2-alkylation of indoles with α-bromo esters catalyzed by Pd/P,P=O system
Tian, Wei,Li, Bowen,Tian, Duanshuai,Tang, Wenjun
supporting information, p. 197 - 200 (2021/08/13)
A palladium-catalyzed 2-alkylation of indoles with α-bromo esters is developed by employing a P,P=O ligand. The method features excellent regioselectivities, mild reaction conditions, and good functional group compatibility. The employment of the P,P=O ligand as well as 4? molecular sieves were crucial for the success of the transformation. Mechanistic studies indicate the reaction proceed through a radical pathway.
A Catalytic One-Pot Synthesis of Indolyl Cyclobutanones
Porcu, Stefania,Rodriguez, Carla Aira,Frongia, Angelo,Secci, Francesco
supporting information, p. 925 - 932 (2020/12/14)
A general strategy for the synthesis of indolyl cyclobutanones via a tandem Bronsted acid catalyzed 2-hydroxycyclobutanone activation-indole nucleophilic addition has been exploited. The procedure leads to a wide range of 2- and 3-functionalized indole derivatives in good to high yields with broad substrate scope.
N-2-pyrimidyl-3-fluoroindole compound and preparation method and application thereof
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Paragraph 0058; 0061, (2021/03/31)
The preparation method of the N-2-pyrimidinyl-3-fluoroindole compound shown in the formula (I) comprises the following steps: by taking an acetonitrile solvent as a reaction medium, adding the N-2-pyrimidinyl indole compound shown in the formula (III), se
