3378-63-0

Basic information

• Product Name: 3,5,5-trimethylhexylamine
• Synonyms: 3,5,5-Trimethylhexylamine; AI3-22315; 1-Hexanamine, 3,5,5-trimethyl-; 3,5,5-trimethylhexan-1-amine
• CAS NO: 3378-63-0
• Molecular Formula: C₉H₂₁N
• Molecular Weight: 143.2697
• EINECS: 222-177-5
• Mol File: 3378-63-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 178°C at 760 mmHg
• Flash Point: 53.3°C
• Density: 0.79g/cm³
• Vapor Pressure: 1.01mmHg at 25°C
• Refractive Index: 1.434
• CAS DataBase Reference: 3,5,5-trimethylhexylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5,5-trimethylhexylamine(3378-63-0)
• EPA Substance Registry System: 3,5,5-trimethylhexylamine(3378-63-0)

Safety Data

• Hazardous Substances Data: 3378-63-0(Hazardous Substances Data)

Usage

General Description

3,5,5-Trimethylhexylamine is a chemical compound with the molecular formula C9H21N. It is a tertiary amine that is commonly used in industry as a corrosion inhibitor, surfactant, and as an intermediate in the production of other chemicals. 3,5,5-Trimethylhexylamine is a clear, colorless liquid with a strong odor, and it is soluble in organic solvents such as ethanol and ether. It is considered to be mildly hazardous, with potential irritant effects on the skin and eyes, and it should be handled and stored with caution. Due to its wide range of applications, 3,5,5-Trimethylhexylamine is an important chemical in various industrial processes.

Upstream product

• 3452-97-9 isononanol 
• 3302-10-1 3,5,5-trimethylhexanoic acid 
• 5435-64-3 3,5,5-trimethyl hexanal 

Downstream Products

• 926-75-0 bis(3,5,5-trimethylhexyl)amine 
• 5435-64-3 3,5,5-trimethyl hexanal 

Relevant articles and documents

One-pot reductive amination of carboxylic acids: a sustainable method for primary amine synthesis

The reductive amination of carboxylic acids is a very green, efficient and sustainable method for the production of (bio-based) amines. However, with current technology, this reaction requires two to three reaction steps. Here, we report the first (heterogeneous) catalytic system for the one-pot reductive amination of carboxylic acids to amines, with solely H2 and NH3 as the reactants. This reaction can be performed with relatively cheap ruthenium-tungsten bimetallic catalysts in the green and benign solvent cyclopentyl methyl ether (CPME). Selectivities of up to 99% for the primary amine could be achieved at high conversions. Additionally, the catalyst is recyclable and tolerant for common impurities such as water and cations (e.g. sodium carboxylate).

Method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds

The invention discloses a method for preparing primary amine by catalyzing reductive amination of aldehyde ketone compounds. The method comprises the following steps: 1) mixing nickel nitrate hexahydrate, citric acid and an organic solvent, carrying out heating and stirring until a colloidal material is obtained, drying the colloidal material, roasting the colloidal material in a protective atmosphere, pickling, washing and drying a roasted product, and performing a partial oxidation reaction on a dried product in an oxygen-nitrogen mixed atmosphere to obtain a catalyst for a reductive amination reaction; and 2) mixing aldehyde or ketone compounds, a methanol solution of ammonia and the reductive amination reaction catalyst, introducing hydrogen, and carrying out a reductive amination reaction. The method has the advantages of high primary amine yield, high selectivity, wide aldehyde ketone substrate range, short reaction time, mild reaction conditions, low cost, greenness, economicalperformance and the like; the used reductive amination reaction catalyst can be recycled more than 10 times, and the catalytic activity of the catalyst is not obviously changed in gram-level reactions; and the method is suitable for large-scale application.