3384-04-1

Basic information

• Product Name: (3-chloropropoxy)benzene
• Synonyms: 1-Phenoxy-3-chloropropane;3-Phenoxy-1-chloropropane;NSC 404105;(3-Chloropropoxy)
• CAS NO: 3384-04-1
• Molecular Formula: C₉H₁₁ClO
• Molecular Weight: 170.64
• EINECS: 222-192-7
• Mol File: 3384-04-1.mol
• Article Data: 20

Chemical Properties

• Melting Point: 12°C
• Boiling Point: 241.51°C (rough estimate)
• Flash Point: 175.2°C
• Appearance: /
• Density: 1.1167
• Vapor Pressure: 0.0338mmHg at 25°C
• Refractive Index: 1.5235 (estimate)
• CAS DataBase Reference: (3-chloropropoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (3-chloropropoxy)benzene(3384-04-1)
• EPA Substance Registry System: (3-chloropropoxy)benzene(3384-04-1)

Safety Data

• Hazardous Substances Data: 3384-04-1(Hazardous Substances Data)

Usage

General Description

(3-chloropropoxy)benzene is a chemical compound with the molecular formula C9H11ClO. It is a chlorinated alkyl ether that consists of a benzene ring with a propoxy group and a chlorine atom attached. (3-chloropropoxy)benzene is commonly used as a solvent, chemical intermediate, and in the production of pharmaceuticals and agrochemicals. It has a variety of industrial applications, including use as a raw material in the synthesis of dyes, fragrances, and flavors. (3-chloropropoxy)benzene is also used as a reagent in organic synthesis and research. It is important to handle this compound with caution, as it is a flammable liquid and may pose health risks if not properly managed.

InChI:InChI=1/C9H11ClO/c10-7-4-8-11-9-5-2-1-3-6-9/h1-3,5-6H,4,7-8H2

Upstream product

• 109-70-6 1.3-chlorobromopropane 
• 108-95-2 phenol 
• 64-17-5 ethanol 
• 627-30-5 1-chloro-3-hydroxypropane 
• 71-43-2 benzene 
• 78-99-9 1,1-dichloropropane 
• 100-67-4 potassium phenolate 
• 142-28-9 1,3-Dichloropropane 
• 141-52-6 sodium ethanolate 
• 6180-61-6 3-phenoxypropanol 

Downstream Products

• 116871-18-2 1-(3-phenoxy-propyl)-pyrrolidine 
• 32599-03-4 1-(3-phenoxypropyl)piperidine 
• 865086-04-0 N-(3-phenoxypropyl)-isoindoline 
• 859201-71-1 (3-phenoxy-propyl)-propyl-malonic acid diethyl ester 
• 854658-80-3 2-cyano-5-phenoxy-valeric acid ethyl ester 
• 6345-89-7 (3-phenoxypropyl)diethyl propanedioate 
• 154287-22-6 1-<4-(3-chloropropoxy)phenyl>-2-phenyl-1-butanone 
• 64010-38-4 1-bromo-4-(3-chloropropoxy)benzene 
• 187737-37-7 propene 
• 10125-18-5 1,6-diphenoxyhexane 
• 139-02-6 sodium phenoxide 
• 2430-76-4 6-phenyl-1,4-hexanediol 
• 92635-89-7 (pent-4-yn-1-yloxy)benzene 

Relevant articles and documents

3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypropylamine analogs of irdabisant (CEP-26401) as potent histamine-3 receptor inverse agonists with robust wake-promoting activity

A novel series of 3,4-diaza-bicyclo[4.1.0]hept-4-en-2-ones were designed and synthesized as H3R analogs of irdabisant 6. Separation of the isomers, assignment of the stereochemistry by crystallography, and detailed profiling of diastereomers 25 and 26 led to the identification of (1R,6S)-5-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)propoxy]phenyl}-3,4-diaza-bicyclo[4.1.0]hept-4-en-2-one 25 as a potential second generation H3R candidate. Diastereomer 25 had high H3R binding affinity, excellent selectivity, displayed potent H3R functional antagonism and robust wake-promoting activity in vivo, and showed acceptable pharmacokinetic and pharmaceutical profiles for potential further development.

Halogenation through Deoxygenation of Alcohols and Aldehydes

An efficient reagent system, Ph3P/XCH2CH2X (X = Cl, Br, or I), was very effective for the deoxygenative halogenation (including fluorination) of alcohols (including tertiary alcohols) and aldehydes. The easily available 1,2-dihaloethanes were used as key reagents and halogen sources. The use of (EtO)3P instead of Ph3P could also realize deoxy-halogenation, allowing for a convenient purification process, as the byproduct (EtO)3Pa?O could be removed by aqueous washing. The mild reaction conditions, wide substrate scope, and wide availability of 1,2-dihaloethanes make this protocol attractive for the synthesis of halogenated compounds.

Process for the preparation of 3-aroyl-5-aminobenzofuran derivatives

The present invention relates to a process for the preparation of 3-aroyl-5-aminobenzofuran derivatives useful as antiarrhythmic drugs which avoids the use of nitro intermediates.